Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NITRERGIC AND CHOLINERGIC INNERVATION OF THE RAT LOWER URINARY-TRACT AFTER PELVIC GANGLIONECTOMY
Autore:
PERSSON K; ALM P; UVELIUS B; ANDERSSON KE;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT PATHOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 389 - 397
SICI:
0363-6119(1998)43:2<389:NACIOT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; L-ARGININE; INTRAMURAL NEURONS; NERVOUS-SYSTEM; BLADDER; URETHRA; NERVES; RELAXATION; NITROVASODILATORS; SUPERSENSITIVITY;
Keywords:
NITRIC OXIDE SYNTHASE; CHOLINE ACETYLTRANSFERASE; MAJOR PELVIC GANGLION; BLADDER; URETHRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K. Persson et al., "NITRERGIC AND CHOLINERGIC INNERVATION OF THE RAT LOWER URINARY-TRACT AFTER PELVIC GANGLIONECTOMY", American journal of physiology. Regulatory, integrative and comparative physiology, 43(2), 1998, pp. 389-397

Abstract

The possible coexistence of nitric oxide (NO) and acetylcholine in the rat major pelvic ganglion (MPG) was examined by double immunohistochemistry using antisera raised against NO synthase (NOS) and choline acetyltransferase (ChAT). The smooth muscle responses of the isolated bladder and urethra were recorded after bilateral cryoganglionectomy of the MPG, focusing on the possible development of denervation supersensitivity. In the MPG, NOS immunoreactivity (ir) was seen in a large number of cell bodies, but it was not as abundant as ChAT-ir cell bodies. Double immunolabeling showed that all NOS-ir cell bodies also displayed ChAT-ir. In ganglionectomized bladders, the electrical field stimulation (EFS)-evoked contractile response was markedly reduced. When compared with control bladders, detrusor strips from ganglionectomized rats were more sensitive to carbachol as revealed by a lower negative logarithm of the drug concentration eliciting 50% relaxation (6.5 +/- 0.04 vs. 5.9 +/- 0.07). In the urethra, the NO-mediated relaxant response to EFS was practically abolished by ganglionectomy, whereas no difference was found in sensitivity to 3-morpholinosydnonimine hydrochloride (SIN-1). SIN-1 produced an equal increase in tissue levels of guanosine 3',5'-cyclic monophosphate in urethral preparations from control and ganglionectomized rats. The results suggest that the NOS-ir nerves that mediate inhibition of rat urethral smooth muscle tone originate from the MPG and contain ChAT. No denervation supersensitivity to nitrergic stimulation was observed in the urethra after ganglionectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:47:40