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Titolo:
AREA POSTREMA LESION ATTENUATES THE LONG-TERM HYPOTENSIVE EFFECTS OF LOSARTAN IN SALT-REPLETE RATS
Autore:
COLLISTER JP; OSBORN JW;
Indirizzi:
UNIV MINNESOTA,DEPT ANIM SCI,1988 FITCH AVE,RM 435 ST PAUL MN 55108 UNIV MINNESOTA,DEPT ANIM SCI ST PAUL MN 55108 UNIV MINNESOTA,DEPT VET PATHOBIOL ST PAUL MN 55108 UNIV MINNESOTA,DEPT PHYSIOL ST PAUL MN 55108
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 357 - 366
SICI:
0363-6119(1998)43:2<357:APLATL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ARTERIAL BLOOD-PRESSURE; ANGIOTENSIN-II HYPERTENSION; SOLITARY TRACT; CIRCUMVENTRICULAR ORGANS; DEPENDENT HYPERTENSION; CARDIOVASCULAR CONTROL; FOOD-INTAKE; MECHANISMS; BRAIN;
Keywords:
CIRCUMVENTRICULAR ORGAN; ANGIOTENSIN II; FOOD RESTRICTION; CHRONIC ARTERIAL PRESSURE REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Collister e J.W. Osborn, "AREA POSTREMA LESION ATTENUATES THE LONG-TERM HYPOTENSIVE EFFECTS OF LOSARTAN IN SALT-REPLETE RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 43(2), 1998, pp. 357-366

Abstract

We reported that the AT(1) receptor antagonist losartan decreases arterial pressure in sodium-replete rats and that this response is attenuated in area postrema-lesioned (APx) rats (J. P. Collister, B. J. Hornfeldt, and J. W. Osborn. Hypertension 27: 598-606, 1996). In that study, food intake for the 3-wk period after sham lesion was restricted tothat observed in APx rats. Food-restricted sham rats had lower arterial pressures and attenuated responses to losartan compared with control rats fed ad libitum. The present study examined whether these differences persisted months, rather than weeks after APx or sham lesions. Losartan was administered for 10 days to APx and two groups of sham rats 3 mo after APx or sham surgery. The first sham group was food restricted (SFR) for 3 wk after surgery, whereas the second sham group was allowed ad libitum (SAL) access to food. By day 8 of losartan administration, both sham groups demonstrated a marked hypotension (SFR: -38 +/- 4; SAL: -33 +/- 4 mmHg). This response was attenuated (P < 0.05) on the same day in APx rats (-17 +/- 3 mmHg). This trend continued throughout days 9 and 10. Because both sham groups responded similarly to losartan (yet significantly different from APx rats), these results demonstrate that transient decreases in food intake do not affect the response to losartan if rats are allowed an adequate recovery period. We conclude that the area postrema mediates part of the long-term hypotensive effects of AT(1) receptor blockade in the conscious rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:47:47