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Titolo:
THE MANIPULATED MESENCHYMAL STEM-CELLS IN REGENERATED SKELETAL TISSUES
Autore:
NEVO Z; ROBINSON D; HOROWITZ S; HASHARONI A; YAYON A;
Indirizzi:
TEL AVIV UNIV,SACKLER SCH MED,DEPT CLIN BIOCHEM IL-69978 TEL AVIV ISRAEL WEIZMANN INST SCI,DEPT MOL & CELL BIOL IL-76100 REHOVOT ISRAEL ORLAND REG HEALTHCARE SYST,DEPT ORTHOPAED ORLANDO FL 00000 ORLAND REG HEALTHCARE SYST,HLTH SCI CTR ORLANDO FL 00000
Titolo Testata:
Cell transplantation
fascicolo: 1, volume: 7, anno: 1998,
pagine: 63 - 70
SICI:
0963-6897(1998)7:1<63:TMMSIR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROCYTES; CULTURE;
Keywords:
CARTILAGE REPAIR AND REGENERATION; CARTILAGINOUS IMPLANT; CULTURED CELLS IMPLANT; MESENCHYMAL SKELETAL PROGENITOR CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
Z. Nevo et al., "THE MANIPULATED MESENCHYMAL STEM-CELLS IN REGENERATED SKELETAL TISSUES", Cell transplantation, 7(1), 1998, pp. 63-70

Abstract

Ample experimental examples have been accumulated during the last 3 decades indicating the ability of exogenous sources of cultured cells to serve as implants accelerating cartilage regeneration in defects of articular surfaces, In some cases, the repair tissues form complete spatial reconstruction of the defect, In other cases, either the spatialreconstruction is incomplete or the quality of the reparative tissue is inadequate. A delayed pace of endochondral ossification in the deepzones of the subchondral region of the defects, or ossification abovethe tide mark, within the superficial cartilaginous articular regionshave been noted, Therefore, even in this promising approach of biological resurfacing procedure results are not certain, and further investigative research efforts are required, In the current study, a comparison of implantations of various cultured cells of four different sources were tested in an avian system, The reparative tissue outcomes are divided into three grades: full regeneration success, partial success,and failure of regeneration according to qualitative histological parameters and quantitative observation of the gross specimen, Defects that failed to regenerate a completely filled lesion were found to contain cells carrying the preskeletal-precartilaginous characteristic marker of FGFR3., The findings based on the above parameters suggest that autogeneic, chondrocytic-enriched bone marrow derived mesenchymal cells are superior to other cell sources for articular cartilage regeneration, Grafting of defects with these cells results in a 100% success rate, Allogeneic limb bud-derived mesenchymal cells and allogeneic embryonal chondrocytes have both reached a success of 75% of completely filled defects, Allogeneic chondrocytic-enriched bone marrow-derived mesenchymal cells yielded a 31% success rate, Untreated defects completelyfailed to heal, In successfully healed defects no cells of the reparative tissue carry the FGFR3 marker 3 months postimplantation, In partially healed defects, FGFR3 positive staining is present in fibrous cells at the invaginated surface, These latest findings may suggest some kind of proliferation failure in such cases, (C) 1998 Elsevier ScienceInc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:20:53