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Titolo:
GENETIC-MAPPING OF THE CLONED SUBGROUP-A AVIAN-SARCOMA AND LEUKOSIS VIRUS RECEPTOR GENE TO THE TVA LOCUS
Autore:
BATES P; RONG LJ; VARMUS HE; YOUNG JAT; CRITTENDEN LB;
Indirizzi:
UNIV PENN,SCH MED,DEPT MICROBIOL,225 JOHNSON PAVIL,3610 HAMILTON WALKPHILADELPHIA PA 19104 NIH BETHESDA MD 20892 HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOL GENET BOSTON MA 02115 MICHIGAN STATE UNIV,DEPT MICROBIOL,USDA,AVIAN DIS & ONCOL LAB E LANSING MI 48824
Titolo Testata:
Journal of virology
fascicolo: 3, volume: 72, anno: 1998,
pagine: 2505 - 2508
SICI:
0022-538X(1998)72:3<2505:GOTCSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; HOST RANGE; ENVELOPE GLYCOPROTEIN; RETROVIRUSES; DETERMINANTS; INFECTION; BINDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P. Bates et al., "GENETIC-MAPPING OF THE CLONED SUBGROUP-A AVIAN-SARCOMA AND LEUKOSIS VIRUS RECEPTOR GENE TO THE TVA LOCUS", Journal of virology, 72(3), 1998, pp. 2505-2508

Abstract

A chicken gene conferring susceptibility to subgroup A avian sarcoma and leukosis viruses (ASLV-A) was recently identified by a gene transfer strategy. Classical genetic approaches had previously identified a locus, TVA, that controls susceptibility to ASLV-A. Using restriction fragment length polymorphism (RFLP) mapping in inbred susceptible (TVAS) and resistant (TVAR) chicken lines, we demonstrate that in 93 F-2progeny an RFLP for the cloned receptor gene segregates with TVA. From these analyses we calculate that the cloned receptor gene lies within 5 centimorgans of TVA, making it highly probable that the cloned gene is the previously identified locus TVA. The polymorphism that distinguishes the two alleles of TVA in these inbred lines affects the encoded amino acid sequence of the region of Tva that encompasses the viralbinding domain. However, analysis of the genomic sequence encoding this region of Tva in randomly bred chickens suggests that the altered virus binding domain is not the basis for genetic resistance in the chicken lines analyzed.

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Documento generato il 27/11/20 alle ore 22:11:43