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Titolo:
THE NUCLEOTIDE-SEQUENCE AND SPLICED POL MESSENGER-RNA LEVELS OF THE NONPRIMATE SPUMAVIRUS BOVINE FOAMY VIRUS
Autore:
HOLZSCHU DL; DELANEY MA; RENSHAW RW; CASEY JW;
Indirizzi:
CORNELL UNIV,COLL VET MED,DEPT IMMUNOL & MICROBIOL ITHACA NY 14853 CORNELL UNIV,COLL VET MED,DEPT IMMUNOL & MICROBIOL ITHACA NY 14853 CORNELL UNIV,COLL VET MED,VET DIAGNOST LAB ITHACA NY 14853
Titolo Testata:
Journal of virology
fascicolo: 3, volume: 72, anno: 1998,
pagine: 2177 - 2182
SICI:
0022-538X(1998)72:3<2177:TNASPM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; SYNCYTIAL VIRUS; INTERNAL PROMOTER; TRANSGENIC MICE; REVERSE-TRANSCRIPTASE; HUMAN SPUMARETROVIRUS; MESSENGER-RNA; GAG PROTEIN; ENV GENE; 3' END;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Holzschu et al., "THE NUCLEOTIDE-SEQUENCE AND SPLICED POL MESSENGER-RNA LEVELS OF THE NONPRIMATE SPUMAVIRUS BOVINE FOAMY VIRUS", Journal of virology, 72(3), 1998, pp. 2177-2182

Abstract

We have determined the complete nucleotide sequence of a replication-competent clone of bovine foamy virus (BFV) and have quantitated the amount of splice pol mRNA processed early in infection. The 544-amino-acid Gag protein precursor has little sequence similarity with its primate foamy virus homologs, but the putative nucleocapsid (NC) protein, like the primate NCs, contains the three glycine-arginine-rich regionsthat are postulated to bind genomic RNA during virion assembly. The BFV gag and pol open reading frames overlap, with pro and pol in the same translational frame. As with the human foamy virus (HEV) and felinefoamy virus, we have detected a spliced pol mRNA by PCR. Quantitatively, this mRNA approximates the level of full-length genomic RNA early in infection. The integrase (IN) domain of reverse transcriptase does not contain the canonical HH-CC zinc finger motif present in all characterized retroviral INs, but it does contain a nearby histidine residue that could conceivably participate as a member of the zinc finger. The env gene encodes a protein that is over 40% identical in sequence to the HFV Env. By comparison, the Gag precursor of BFV is predicted tobe only 28% identical to the HFV protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:51:02