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Titolo:
NEUTRALIZATION SENSITIVITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PRIMARY ISOLATES TO ANTIBODIES AND CD4-BASED REAGENTS IS INDEPENDENT OF CORECEPTOR USAGE
Autore:
TRKOLA A; KETAS T; KEWALRAMANI VN; ENDORF F; BINLEY JM; KATINGER H; ROBINSON J; LITTMAN DR; MOORE JP;
Indirizzi:
ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,455 1ST AVE,7TH FLOOR NEWYORK NY 10016 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR NEW YORK NY 10016 NYU,SCH MED,SKIRBALL INST BIOMOL MED NEW YORK NY 10016 HOWARD HUGHES MED INST NEW YORK NY 10016 AGR UNIV VIENNA,INST APPL MICROBIOL A-1180 VIENNA AUSTRIA TULANE UNIV,MED CTR,DEPT PEDIAT NEW ORLEANS LA 70112
Titolo Testata:
Journal of virology
fascicolo: 3, volume: 72, anno: 1998,
pagine: 1876 - 1885
SICI:
0022-538X(1998)72:3<1876:NSOHTP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONOCLONAL-ANTIBODY; SYNCYTIUM-INDUCING PHENOTYPE; INFECTIOUS MOLECULAR CLONE; AMINO-ACID SUBSTITUTIONS; SOLUBLE CD4; VIRAL PHENOTYPE; IN-VIVO; ENVELOPE GLYCOPROTEIN; BIOLOGICAL PHENOTYPE; DISEASE PROGRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
107
Recensione:
Indirizzi per estratti:
Citazione:
A. Trkola et al., "NEUTRALIZATION SENSITIVITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PRIMARY ISOLATES TO ANTIBODIES AND CD4-BASED REAGENTS IS INDEPENDENT OF CORECEPTOR USAGE", Journal of virology, 72(3), 1998, pp. 1876-1885

Abstract

We have investigated whether the identity of the coreceptor (CCR5, CXCR4, or both) used by primary human immunodeficiency virus type 1 (HIV-1) isolates to enter CD4(+) cells influences the sensitivity of theseisolates to neutralization by monoclonal antibodies and CD4-based agents, Coreceptor usage was not an important determinant of neutralization titer for primary isolates in peripheral blood mononuclear cells. We also studied whether dualtropic primary isolates (able to use both CCR5 and CXCR4) were differentially sensitive to neutralization by the same antibodies when entering U87MG-CD4 cells stably expressing eitherCCR5 or CXCR4. Again, we found that the coreceptor used by a virus did not greatly affect its neutralization sensitivity. Similar results were obtained for CCR5- or CXCR4-expressing HOS cell lines engineered to express green fluorescent protein as a reporter of HIV-1 entry. Neutralizing antibodies are therefore unlikely to be the major selection pressure which drives the phenotypic evolution (change in coreceptor usage) of HIV-l that can occur in vivo. In addition, the increase in neutralization sensitivity found when primary isolates adapt to growth intransformed cell lines in vitro has little to do with alterations in coreceptor usage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:52:16