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Titolo:
SIMULTANEOUS MEASUREMENT OF MYOCARDIAL OXYGEN-CONSUMPTION AND BLOOD-FLOW USING [1-CARBON-11]ACETATE
Autore:
SUN KT; YEATMAN LA; BUXTON DB; CHEN KW; JOHNSON JA; HUANG SC; KOFOED KF; WEISMUELLER S; CZERNIN J; PHELPS ME; SCHELBERT HR;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MOL & MED PHARMACOL,LAB STRUCT BIOL & MOL MED,DIV NUCL MED LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,DEPT MOL & MED PHARMACOL,LAB STRUCT BIOL & MOL MED,DIV NUCL MED LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,DIV CARDIOL LOS ANGELES CA 90095
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 2, volume: 39, anno: 1998,
pagine: 272 - 280
SICI:
0161-5505(1998)39:2<272:SMOMOA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 ACETATE; OXIDATIVE-METABOLISM; N-13 AMMONIA; NONINVASIVE ASSESSMENT; RAT-HEART; PET; TRACER; VALIDATION; CARBON-11-ACETATE;
Keywords:
PET; MYOCARDIAL OXYGEN CONSUMPTION; MYOCARDIAL BLOOD FLOW; [1-CARBON-11]ACETATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K.T. Sun et al., "SIMULTANEOUS MEASUREMENT OF MYOCARDIAL OXYGEN-CONSUMPTION AND BLOOD-FLOW USING [1-CARBON-11]ACETATE", The Journal of nuclear medicine, 39(2), 1998, pp. 272-280

Abstract

[1-Carbon-11]acetate has been used as a racer-for oxidative metabolism with PET; The aim of this study was to validate, in humans, a previously proposed two-compartment model for [1-C-11]acetate for the noninvasive measurement of myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) with PET. Methods: Twelve healthy volunteers were studied with [N-13]ammonia, [1-C-11]acetate and PET. Myocardial oxygenconsumption was invasively determined by the Fick method from arterial and coronary sinus O-2 concentrations and from MBF obtained by [N-13]ammonia PET. Results: Directly measured MVO2 ranged from 5.2 id 11.1 ml/100 g/min, and MBF ranged from 0.48 to 0.88 ml/g/min. Oxidative flux through the tricarboxylic acid cycle, reflected by the rate constantk(2), which correlated linearly with measured MVO2 [k(2) = 0.0071 + 0.0074(MVO2); r = 0.74, s.e.e. = 0.015]. With this correlation, MVO2 could-be estimated from the model-derived k(2) value by MVO2 = 135(k(2))-0.96, The slope of this relationship was close to that previously obtained in rats and implies that the tricarboxylic acid cycle intermediate metabolite pool sizes are comparable. The net extraction (K-1) of [1-C-11]acetate, measured by PET, from blood into myocardium correlated closely with MBF by K-1 = 0.15 + 0.73(MBF) (r = 0.93, s.e.e. = 0.033)and, thus, provided noninvasively obtainable measures of blood flow. Conclusion: The proposed compartment model for [1-C-11]acetate fits the measured kinetics well and, with proper calibration, allows estimation of absolute MVO, rather than only an index of oxidative metabolism. Furthermore, [1-C-11]acetate-derived estimates of MBF are feasible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:33:25