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Titolo:
AN EXPRESSION OF ANAPLASTIC LARGE-CELL LYMPHOMA-ASSOCIATED ANTIGENS ON HTLV-I-INFECTED CD4(-CELLS() T)
Autore:
MAKINO M; YASHIKI S; FUJIYOSHI T; BABA M; SONODA S;
Indirizzi:
KAGOSHIMA UNIV,FAC MED,DIV HUMAN RETROVIRUSES,CTR CHRON VIRAL DIS,8-35-1 SAKURAGAOKA KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN
Titolo Testata:
Annals of hematology
fascicolo: 1, volume: 76, anno: 1998,
pagine: 31 - 35
SICI:
0939-5555(1998)76:1<31:AEOALL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-I; LYMPHOCYTES-T; LEUKEMIA; GENE; ACTIVATION; P40(TAX); BLOOD; CD80;
Keywords:
ADULT T-CELL LEUKEMIA; HTLV-I; TUMOR-ASSOCIATED ANTIGENS; ANAPLASTIC LARGE CELL LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Makino et al., "AN EXPRESSION OF ANAPLASTIC LARGE-CELL LYMPHOMA-ASSOCIATED ANTIGENS ON HTLV-I-INFECTED CD4(-CELLS() T)", Annals of hematology, 76(1), 1998, pp. 31-35

Abstract

We investigated tumor-associated antigens induced by infection with human T-lymphotropic virus type I(HTLV-I). Anaplastic large cell lymphoma (APLL) antigens were found to be expressed on interleukin 2 (IL-2)-dependent, HTLV-I-infected CD4(+) T-cell lines established from patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. However, APLL antigens were not detected on unstimulated lymphocytes, mitogen-activated T lymphocytes, or Epstein-Barr virus-infected B cells. Furthermore, APLL antigens were not found onIL-2-independent HTLV-I-transformed cells such as MT-1 or MT-2. When naive CD4(+) T cells were infected with HTLV-I in vitro in the presence of IL-2, the APLL antigens were detected on them 4 weeks after infection. The expression level increased in a time-dependent fashion. These results indicate that HTLV-I infection induces a unique category of tumor-associated antigens on CD4(+) T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:24:26