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Titolo:
(R)SALSOLINOL N-METHYLTRANSFERASE ACTIVITY INCREASES IN PARKINSONIAN LYMPHOCYTES
Autore:
NAOI M; MARUYAMA W; NAKAO N; IBI T; SAHASHI K; BENEDETTI MS;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU,GOKISO CHO NAGOYA AICHI 4668555 JAPAN NATL INST LONGEV SCI,DEPT BASIC GERONTOL,BIOCHEM & METAB LAB NAGAKUTEAICHI JAPAN AICHI MED UNIV,NEUROL SECT NAGAKUTE AICHI 48011 JAPAN ZAMBON GRP,PRECLIN DEV & HUMAN PHARMACOL MILAN ITALY
Titolo Testata:
Annals of neurology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 212 - 216
SICI:
0364-5134(1998)43:2<212:(NAIIP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC NEUROTOXIN; DISEASE; METHYLATION; PRECURSOR; PYRIDINES; RAT; ION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Naoi et al., "(R)SALSOLINOL N-METHYLTRANSFERASE ACTIVITY INCREASES IN PARKINSONIAN LYMPHOCYTES", Annals of neurology, 43(2), 1998, pp. 212-216

Abstract

Recently, an endogenous catechol isoquinoline, ethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl(R)salsolinol], was proved to bea neurotoxin specific for dopamine neurons by in vivo and in vitro experiments. This N-methyl(R)salsolinol was found to increase significantly in the cerebrospinal fluid of untreated parkinsonian patients, suggesting its possible involvement in the pathogenesis of Parkinson's disease, To clarify the mechanism of the increase, the activity of enzymes related to the metabolism of the neurotoxin was examined in lymphocytes prepared from parkinsonian patients and controls. In patients with Parkinson's disease, the activity of a neutral N-methyltransferase, measured by using (R)salsolinol as a substrate, was found to increase significantly (100.2 +/- 81.8 pmol/min/mg of protein) in comparison with that in controls (18.9 +/- 15.0 pmol/min/mg of protein). The distribution of the activity was bimodal in the parkinsonian patients, whereas it was singular in controls, The activity of other related enzymes,an alkaline N-methyltransferase and N-methyl(R)salsolinol oxidase, inparkinsonian lymphocytes was the same as in controls. Increase of theneutral N-methyltransferase may be an endogenous factor in the pathogenesis of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:50:44