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Titolo:
DIFFUSION-WEIGHTED MRI IN TRANSIENT GLOBAL AMNESIA - ELEVATED SIGNAL INTENSITY IN THE LEFT MESIAL TEMPORAL-LOBE IN 7 OF 10 PATIENTS
Autore:
STRUPP M; BRUNING R; WU RH; DEIMLING M; REISER M; BRANDT T;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL,MARCHIONINISTR 15 D-81366 MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT RADIOL D-81366 MUNICH GERMANY SIEMENS MED SYST INC ERLANGEN GERMANY
Titolo Testata:
Annals of neurology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 164 - 170
SICI:
0364-5134(1998)43:2<164:DMITGA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVOXEL INCOHERENT MOTIONS; SPREADING DEPRESSION THEORY; STATE FREE PRECESSION; MIGRAINE ATTACKS; HUMAN-BRAIN; SPECT; AURA; PATHOPHYSIOLOGY; IMPAIRMENT; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Strupp et al., "DIFFUSION-WEIGHTED MRI IN TRANSIENT GLOBAL AMNESIA - ELEVATED SIGNAL INTENSITY IN THE LEFT MESIAL TEMPORAL-LOBE IN 7 OF 10 PATIENTS", Annals of neurology, 43(2), 1998, pp. 164-170

Abstract

Prompted by the findings of previous studies with positron emission tomography and single photon emission computed tomography, which demonstrated hypoperfusion or hyperperfusion in the left temporal lobe in isolated patients with transient global amnesia (TGA), we compared the sensitivity of diffusion-weighted (DW)? magnetic resonance imaging (MRI) with that of conventional T1- and T2-weighted MRI in patients with TGA. Ten patients with the typical syndrome of a pure TGA were includedin the study. For all patients, a coronal DW sequence, a steady-statefree precession (SSFP) sequence, and conventional T1- and T2-weightedturbo spin-echo sequences were obtained. Seven of the 10 patients hadelevated signal intensity in the left hippocampal region on DW MRI; moreover, 3 of these 7 patients exhibited bilateral signal abnormality in this sequence. All conventional T1- and T2-weighted images as well as all follow-up studies were normal. The signal elevation in DW MRI correlates with a decrease in the interstitial space and with cellular edema in the temporal lobe during TGA. The underlying pathomechanism causing this cellular edema cannot be clearly outlined using DW MRI. Our data are, however, compatible with spreading depression. This is thefirst study to show that DW MRT is a sensitive MRI method for evaluating TGA, especially in the early stage of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:13:13