Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BRAIN ABNORMALITY IN SCHIZOPHRENIA - A SYSTEMATIC AND QUANTITATIVE REVIEW OF VOLUMETRIC MAGNETIC-RESONANCE-IMAGING STUDIES
Autore:
LAWRIE SM; ABUKMEIL SS;
Indirizzi:
ROYAL EDINBURGH & ASSOCIATED HOSP,DEPT PSYCHIAT EDINBURGH EH10 5HF MIDLOTHIAN SCOTLAND
Titolo Testata:
British Journal of Psychiatry
, volume: 172, anno: 1998,
pagine: 110 - 120
SICI:
0007-1250(1998)172:<110:BAIS-A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR TEMPORAL GYRUS; GRAY-MATTER VOLUME; FIRST-EPISODE SCHIZOPHRENIA; VENTRICULAR SYSTEM; PREFRONTAL CORTEX; THOUGHT-DISORDER; LOBE; MRI; MORPHOLOGY; METAANALYSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Lawrie e S.S. Abukmeil, "BRAIN ABNORMALITY IN SCHIZOPHRENIA - A SYSTEMATIC AND QUANTITATIVE REVIEW OF VOLUMETRIC MAGNETIC-RESONANCE-IMAGING STUDIES", British Journal of Psychiatry, 172, 1998, pp. 110-120

Abstract

Background Numerous in vivo brain imaging studies suggest that cerebral structure is abnormal in schizophrenia, but implicate different regions to varying extents. Method We identified published MRI studies inschizophrenia with searches of the computerised literature and key journals. Reports giving the volumes of cortical structures in people with schizophrenia and controls were included. The percentage differences in volumes were calculated and the median taken as a summary measurefor each brain region. Results Forty relevant studies were identified. The median percentage volume differences revealed overall reductionsin the whole brain (3%), temporal robe (6% left, 9.5% right), and theamygdala/hippocampal complex (6.5%, 5.5%); and increases in the lateral ventricles (44%, 36%), that were greatest in the body and occipitalhorns. Segmentation studies suggest that grey matter is reduced but that white matter volumes may actually be increased. In men, substantial reductions were also evident in the amygdala and hippocampus, as well as the largest reductions of all in the parahippocampus (14%, 9%). Few studies gave figures for women alone. Conclusions Several brain structures in schizophrenia are affected to a greater extent than expected from overall reductions in brain volume. Further studies are required in affected women, and to try to identify clinical and aetiological associations of these findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:37:35