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Titolo:
ESTIMATION OF ORGAN CUMULATED ACTIVITIES AND ABSORBED DOSES ON INTAKES OF SEVERAL C-11 LABELED RADIOPHARMACEUTICALS FROM EXTERNAL MEASUREMENT WITH THERMOLUMINESCENT DOSIMETERS
Autore:
NAKAMURA T; HAYASHI Y; WATABE H; MATSUMOTO M; HORIKAWA T; FUJIWARA T; ITO M; YANAI K;
Indirizzi:
TOHOKU UNIV,CTR CYCLOTRON & RADIOISOTOPE SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Physics in medicine and biology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 389 - 405
SICI:
0031-9155(1998)43:2<389:EOOCAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOIMMUNOTHERAPY; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Nakamura et al., "ESTIMATION OF ORGAN CUMULATED ACTIVITIES AND ABSORBED DOSES ON INTAKES OF SEVERAL C-11 LABELED RADIOPHARMACEUTICALS FROM EXTERNAL MEASUREMENT WITH THERMOLUMINESCENT DOSIMETERS", Physics in medicine and biology, 43(2), 1998, pp. 389-405

Abstract

We have developed a method for obtaining the cumulated activities in organs from radionuclides, which are injected into the patient in nuclear medicine procedures, by external exposure measurement with thermoluminescent dosimeters (TLDs) which are attached to the patient's body surface close to source organs to obtain information on body-surface doses. As the surface dose is connected to the cumulated activities in source organs through radiation transmission in the human body which can be estimated with the aid of a mathematical phantom, the organ cumulated activities can be obtained by the inverse transform method. The accuracy of this method was investigated by using a water phantom in which several gamma-ray volume sources of known activity were placed tosimulate source organs. We then estimated by external measurements the organ cumulated activities and absorbed doses in subjects to whom the radiopharmaceuticals C-11-labelled Doxepin, C-11-labelled YM09151-2 and C-11-labelled Benzotropin were administered in clinical nuclear medicine procedures. The cumulated activities in the brain obtained withTLDs for Doxepin and YM09151-2 are 63.6+/-6.2 and 32.1 +/- 12.0 kBq hMBq(-1) respectively, which are compared with the respective values of 33.3 +/- 9.9 and 23.9 +/- 6.2 kBq h MBq(-1) with direct PET (positron emission tomography) measurements. The agreement between the two methods is within a factor of two. The effective doses of Doxepin, YM09151-2 and Benzotropin are determined as 6.92 x 10(-3), 7.08 x 10(-3) and7.65 x 10(-3) mSv MBq(-1) respectively with the TLD method. This method has great advantages, in that cumulated activities in several organs can be obtained easily with a single procedure, and the measurementsof body surface doses are performed simultaneously with the nuclear medicine procedure, as TLDs are too small to interfere with other medical measurements.

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Documento generato il 22/10/20 alle ore 09:10:15