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Titolo:
INCREASED SERUM LEVELS OF TRANSFORMING GROWTH-FACTOR-ALPHA IN PATIENTS WITH COLORECTAL-CANCER
Autore:
SHIM KS; KIM KH; PARK BW; YI SY; CHOI JH; HAN WS; PARK EB;
Indirizzi:
EWHA WOMANS UNIV,MOKDONG HOSP,DEPT GEN SURG,YANGCHEON KU,911-1 MOKDONG SEOUL SOUTH KOREA EWHA WOMANS UNIV,COLL MED,DEPT GEN SURG SEOUL SOUTH KOREA EWHA WOMANS UNIV,COLL MED,DEPT INTERNAL MED SEOUL SOUTH KOREA EWHA WOMANS UNIV,COLL MED,EWHA MED RES CTR,DEPT PATHOL SEOUL SOUTH KOREA AJOU UNIV,SCH MED,DEPT HEMATOL ONCOL SUWON 441749 SOUTH KOREA
Titolo Testata:
Diseases of the colon & rectum
fascicolo: 2, volume: 41, anno: 1998,
pagine: 219 - 224
SICI:
0012-3706(1998)41:2<219:ISLOTG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-COLON-CARCINOMA; CELL-LINE; EXPRESSION; PROLIFERATION; OLIGONUCLEOTIDES; PROGRESSION; MODEL;
Keywords:
COLORECTAL CANCER; TRANSFORMING GROWTH FACTOR-ALPHA; ENZYME-LINKED IMMUNOADSORBENT ASSAY; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Shim et al., "INCREASED SERUM LEVELS OF TRANSFORMING GROWTH-FACTOR-ALPHA IN PATIENTS WITH COLORECTAL-CANCER", Diseases of the colon & rectum, 41(2), 1998, pp. 219-224

Abstract

PURPOSE: This study was conducted to investigate the serum levels of transforming growth factor-alpha in patients with colorectal cancer and to investigate the clinical significance of these levels in association with tumor stage and histologic differentiation. Also, serum levels of transforming growth factor-alpha were measured after curative surgical resection. METHODS: Serum levels of transforming growth factor-alpha were measured in 42 consecutive patients with colorectal cancer before surgery, in 21 patients after surgical resection (part of the 42preoperative patients), and in 20 healthy volunteers. We used TGF-alpha Assay(TM). RESULTS: Serum levels of transforming growth factor-alpha in patients with colorectal cancer were significantly higher than inthe healthy control group (P = 0.001). Significant elevations in serum levels of transforming growth factor-alpha were found in 50 percent (21/42) of patients with colorectal cancer when the mean + 2 standard deviations (80.4 pg/ml) of the control group were used as the upper limit of the normal range. Serum levels of transforming growth factor-alpha tended to decrease with increasing tumor size (n = 31; r = -0.52; P = 0.002). Serum levels of transforming growth factor-alpha before surgery (89.7 +/- 44.4 pg/ml; n = 21) significantly decreased to 60.3 +/- 19.8 pg/ml after surgical resections of tumors (P = 0.017). Serum levels of transforming growth factor-alpha completely decreased to the same serum levels of the control group after surgical resections in allpatients who had serum levels of transforming growth factor-alpha greater than mean + 2 standard deviations (80.4 pg/ml) of the control group preoperatively (n = 11; P = 0.002). CONCLUSIONS: Levels of preoperative transforming growth factor-alpha in patients with colorectal cancer appeared to be higher than levels measured in control subjects. Serum levels of transforming growth factor-alpha before surgery significantly decreased after surgical resections of tumors. Additional studiesare warranted to determine if serum levels of transforming growth factor-alpha may be useful as a potential biomarker in the management of patients with colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:45:18