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Titolo:
IDENTIFICATION OF A CULLIN HOMOLOGY REGION IN A SUBUNIT OF THE ANAPHASE-PROMOTING COMPLEX
Autore:
YU HT; PETERS JM; KING RW; PAGE AM; HIETER P; KIRSCHNER MW;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT CELL BIOL,240 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT CELL BIOL BOSTON MA 02115 UNIV BRITISH COLUMBIA,CTR MOL MED & THERAPEUT VANCOUVER BC V6R 2X8 CANADA
Titolo Testata:
Science
fascicolo: 5354, volume: 279, anno: 1998,
pagine: 1219 - 1222
SICI:
0036-8075(1998)279:5354<1219:IOACHR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID SEPARATION; SACCHAROMYCES-CEREVISIAE; UBIQUITIN LIGASE; MITOTIC CYCLINS; CELL-CYCLE; PROTEOLYSIS; DESTRUCTION; TRANSITION; YEAST; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H.T. Yu et al., "IDENTIFICATION OF A CULLIN HOMOLOGY REGION IN A SUBUNIT OF THE ANAPHASE-PROMOTING COMPLEX", Science, 279(5354), 1998, pp. 1219-1222

Abstract

The anaphase-promoting complex is composed of eight protein subunits,including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8). The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned. APC7 contains multiple copies of thetetratrico peptide repeat, similar to CDC16, CDC23, and CDC27. Whereas APC4 and APC5 share no similarity to proteins of known function, APC2 contains a region that is similar to a sequence in cullins, a familyof proteins implicated in the ubiquitination of G(1) phase cyclins and cyclin-dependent kinase inhibitors. The APC2 gene is essential in Saccharomyces cerevisiae, and apc2 mutants arrest at metaphase and are defective in the degradation of Pds1p. APC2 and cullins may be distantly related members of a ubiquitin ligase family that targets cell cycleregulators for degradation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:33:13