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Titolo:
MASS-SPECTROMETRIC ANALYSIS OF THE ANAPHASE-PROMOTING COMPLEX FROM YEAST - IDENTIFICATION OF A SUBUNIT RELATED TO CULLINS
Autore:
ZACHARIAE W; SHEVCHENKO A; ANDREWS PD; CIOSK R; GALOVA M; STARK MJR; MANN M; NASMYTH K;
Indirizzi:
EUROPEAN MOL BIOL LAB,MEYERHOFSTR 1 D-69012 HEIDELBERG GERMANY EUROPEAN MOL BIOL LAB D-69012 HEIDELBERG GERMANY RES INST MOL PATHOL A-1030 VIENNA AUSTRIA UNIV DUNDEE,DEPT BIOCHEM DUNDEE DD1 4HN SCOTLAND
Titolo Testata:
Science
fascicolo: 5354, volume: 279, anno: 1998,
pagine: 1216 - 1219
SICI:
0036-8075(1998)279:5354<1216:MAOTAC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID SEPARATION; SACCHAROMYCES-CEREVISIAE; POLYACRYLAMIDE GELS; CYCLIN; UBIQUITIN; PROTEINS; TRANSITION; FAMILY; PROTEOLYSIS; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W. Zachariae et al., "MASS-SPECTROMETRIC ANALYSIS OF THE ANAPHASE-PROMOTING COMPLEX FROM YEAST - IDENTIFICATION OF A SUBUNIT RELATED TO CULLINS", Science, 279(5354), 1998, pp. 1216-1219

Abstract

Entry into anaphase and exit from mitosis depend on a ubiquitin-protein ligase complex called the anaphase-promoting complex (APC) or cyclosome. At least 12 different subunits were detected in the purified particle from budding yeast, including the previously identified proteinsApc1p, Cdc16p, Cdc23p, Cdc26p, and Cdc27p, Five additional subunits purified in low nanogram amounts were identified by tandem mass spectrometric sequencing, Apc2p, Apc5p, and the RING-finger protein Apc11p are conserved from yeast to humans, Apc2p is similar to the cullin Cdc53p, which is a subunit of the ubiquitin-protein ligase complex SCFCdc4 required for the initiation of DNA replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:44:06