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Titolo:
HBED - A POTENTIAL ALTERNATIVE TO DEFEROXAMINE FOR IRON-CHELATING THERAPY
Autore:
BERGERON RJ; WIEGAND J; BRITTENHAM GM;
Indirizzi:
UNIV FLORIDA,DEPT MED CHEM,BOX 100485 JHMHC GAINESVILLE FL 32610 CASE WESTERN RESERVE UNIV,METROHLTH MED CTR,DEPT MED CLEVELAND OH 00000
Titolo Testata:
Blood
fascicolo: 4, volume: 91, anno: 1998,
pagine: 1446 - 1452
SICI:
0006-4971(1998)91:4<1446:H-APAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-THALASSEMIA; ANAPHYLACTOID REACTIONS; RAPID DESENSITIZATION; CLEARING PROPERTIES; CLINICAL USE; DESFERRIOXAMINE; OVERLOAD; DESFERRITHIOCIN; EFFICACY; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Bergeron et al., "HBED - A POTENTIAL ALTERNATIVE TO DEFEROXAMINE FOR IRON-CHELATING THERAPY", Blood, 91(4), 1998, pp. 1446-1452

Abstract

To examine the potential clinical usefulness of the hexadentate phenolic aminocarboxylate iron chelator N-bis(2-hydroxybenzyl)ethylenediamine-N,N-diacetic acid (HBED) for the chronic treatment of transfusionaliron overload, we compared the iron excretion induced by subcutaneous(SC) injection of HBED and deferoxamine (DFO), the reference chelator, in rodents and primates. In the non-iron-overloaded, bile-duct-cannulated rat. a single SC injection of HBED, 150 mu mol/kg, resulted in anet iron excretion that was more than threefold greater than that after the same dose of DFO. In the iron-loaded Cebus apella monkey, a single SC injection of HBED, 150 mu mol/kg, produced a net iron excretionthat was more than twice that observed after the same dose of SC DFO. In patients with transfusional iron overload, SC injections of HBED may provide a much needed alternative to the use of prolonged parenteral infusions of DFO. (C) 1998 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:39:48