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Titolo:
SOME ASPECTS OF THE EFFECTS OF PL-10.1.AK-15 ON THE GASTROINTESTINAL-TRACT
Autore:
ERCEG D; SIMICEVIC VN; KOLEGA M; DOHOCZKY C;
Indirizzi:
PLIVA PHARMACEUT CORP,RES INST,BIOMED DEPT,PRILAZ BARUNA FILIPOVICA 25 HR-10000 ZAGREB CROATIA
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-5, volume: 91, anno: 1997,
pagine: 179 - 181
SICI:
0928-4257(1997)91:3-5<179:SAOTEO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE; STRESS; RATS; BPC;
Keywords:
PL-10.1.AK-15; BODY PROTECTION COMPOUND; GASTRIC ACID SECRETION; GASTROINTESTINAL MOTILITY; SAFETY PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D. Erceg et al., "SOME ASPECTS OF THE EFFECTS OF PL-10.1.AK-15 ON THE GASTROINTESTINAL-TRACT", J PHYSL-PAR, 91(3-5), 1997, pp. 179-181

Abstract

PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointestinal motility. Gastric acid secretion was assessed in male Wistar rats using a modified method of Shay, while gastrointestinal motility was assessed in male NMRImice by charcoal propulsion. PL-10.1.AK-15 was given in three different doses (3, 10 and 100 mu g/kg body weight) in accordance with the experimental protocol. The results of these experiments indicate that PL-10.1.AK-15 in the investigated doses had no influence on gastric acidsecretion or gastrointestinal motility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/12/20 alle ore 00:02:17