Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BPC 157S EFFECT ON HEALING
Autore:
SEIWERTH S; SIKIRIC P; GRABAREVIC Z; ZORICIC I; HANZEVACKI M; LJUBANOVIC D; CORIC V; KONJEVODA P; PETEK M; RUCMAN R; TURKOVIC B; PEROVIC D; MIKUS D; JANDRIJEVIC S; MEDVIDOVIC M; TADIC T; ROMAC B; KOS J; PERIC J; KOLEGA Z;
Indirizzi:
UNIV ZAGREB,MED & VET FAC,CTR DIGEST DIS,INST PATHOL,SALATA 10 ZAGREB10000 CROATIA
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-5, volume: 91, anno: 1997,
pagine: 173 - 178
SICI:
0928-4257(1997)91:3-5<173:>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN; PEPTIDE; WOUNDS; REPAIR; STRESS; BETA; RATS;
Keywords:
BPC; HEALING; SKIN WOUNDS; COLON-COLON ANASTOMOSES; SYNTHETIC SPONGE; RETICULIN; COLLAGEN; HISTOLOGY; MORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Seiwerth et al., "BPC 157S EFFECT ON HEALING", J PHYSL-PAR, 91(3-5), 1997, pp. 173-178

Abstract

The 15 amino acid agent BPC 157, showing a wide range of organoprotective action in different experimental models, was used in our experiments in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importance in the process of healing are formation of granulation tissue, angiogenesis and production of collagen. In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation. The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry. In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process. It is worth noting that these effects were achieved by different routes of application, including intragastric and local, making BPC 157 a potentially useful therapeutic agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:40:25