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Titolo:
PENTADECAPEPTIDE BPC-157 POSITIVELY AFFECTS BOTH NONSTEROIDAL ANTIINFLAMMATORY AGENT-INDUCED GASTROINTESTINAL LESIONS AND ADJUVANT ARTHRITIS IN RATS
Autore:
SIKIRIC P; SEIWERTH S; GRABAREVIC Z; RUCMAN R; PETEK M; JAGIC V; TURKOVIC B; ROTKVIC I; MISE S; ZORICIC I; KONJEVODA P; PEROVIC D; SIMICEVIC V; SEPAROVIC J; HANZEVACKI M; LJUBANOVIC D; ARTUKOVIC B; BRATULIC M; TISLJAR M; REKIC B; GJURASIN M; MIKLIC P; BULJAT G;
Indirizzi:
UNIV ZAGREB,MED & VET FAC,DEPT PHARMACOL,CTR DIGEST DIS,SALATA 11,POB916 ZAGREB 10000 CROATIA
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-5, volume: 91, anno: 1997,
pagine: 113 - 122
SICI:
0928-4257(1997)91:3-5<113:PBPABN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRAINT STRESS; EPITHELIAL PROLIFERATION; RHEUMATOID-ARTHRITIS; DOPAMINE AGONISTS; BOWEL-DISEASE; SUBSTANCE-P; INDOMETHACIN; BPC-157; MODEL; CYTOPROTECTION;
Keywords:
PENTADECAPEPTIDE BPC 157; PEPTIDE BPC; GASTROINTESTINAL LESIONS; ADJUVANT ARTHRITIS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
P. Sikiric et al., "PENTADECAPEPTIDE BPC-157 POSITIVELY AFFECTS BOTH NONSTEROIDAL ANTIINFLAMMATORY AGENT-INDUCED GASTROINTESTINAL LESIONS AND ADJUVANT ARTHRITIS IN RATS", J PHYSL-PAR, 91(3-5), 1997, pp. 113-122

Abstract

Besides a superior protection of the pentadecapeptide BPC 157 (an essential fragment of an organoprotective gastric juice peptide BPC) against different gastrointestinal and liver lesions, an acute anti-inflammatory and analgetic activity was also noted. Consequently, its effecton chronic inflammation lesions, such as adjuvant arthritis, and non-steroidal anti-inflammatory agents (NSAIAs)-induced gastrointestinal lesions was simultaneously studied in rats. In gastrointestinal lesions(indomethacin (30 mg/kg SC), aspirin (400 mg/kg ig) and diclofenac (125 mg/kg ip) studies, BPC 157 (IO mu g or 10 ng/kg ip) was regularly given simultaneously and/or 1 h prior to drug application (indomethacin). In the adjuvant arthritis (tail-application of 0.2 mt of Freund's adjuvant) studies (14 days, 30 days, 1 year) BPC 157 (10 mu g or 10 ng/kg ip), it was given as a single application (at 1 h either before or following the application of Freund's adjuvant) or in a once daily regimen (0-14th day, 14-30th day, 14th day-1 year). Given with the investigated NSAIAs, BPC 157 consistently reduced the otherwise prominent lesions in the stomach of the control rats, as well as the lesions in the small intestine in the indomethacin groups. In the adjuvant arthritis studies, the lesion's development seems to be considerably reduced after single pentadecapeptide medication, and even more attenuated in rats daily treated with BPC 157. As a therapy of already established adjuvant arthritis, its salutary effect consistently appeared already after 2 weeks of medication and it could be clearly seen also after 1 year of application. Taking together all these results, the data likely point to a special anti-inflammatory and mucosal integrity protective effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:24:10