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Titolo:
VALIDATION AND TESTING OF A NEW IONTOPHORETIC CONTINUOUS-FLOW THROUGHTRANSPORT CELL
Autore:
VANDERGEEST R; DANHOF M; BODDE HE;
Indirizzi:
LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV PHARMACOL LEIDEN NETHERLANDS LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV PHARMACOL LEIDEN NETHERLANDS LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV PHARMACEUT TECHNOL,SYLVIUS LAB NL-2300 RA LEIDEN NETHERLANDS
Titolo Testata:
Journal of controlled release
fascicolo: 1, volume: 51, anno: 1998,
pagine: 85 - 91
SICI:
0168-3659(1998)51:1<85:VATOAN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROUGH DIFFUSION CELL; PERCUTANEOUS-ABSORPTION; INVITRO; SYSTEM;
Keywords:
IONTOPHORESIS; IN VITRO; APOMORPHINE; TRANSPORT KINETICS; DIFFUSION CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Vandergeest et al., "VALIDATION AND TESTING OF A NEW IONTOPHORETIC CONTINUOUS-FLOW THROUGHTRANSPORT CELL", Journal of controlled release, 51(1), 1998, pp. 85-91

Abstract

A new continuous flow through transport cell is presented. The designis based on a minimisation of contributions of the cell conformation and experimental protocol to the overall transport kinetics. The system is validated by measuring the washout period of methylene blue and apomorphine. Preliminary results on the iontophoretic transport of apomorphine across human stratum corneum are presented. These data are used to calculate the deviation of the measured apparent flux from the calculated intrinsic flux across the membrane. The steady state iontophoretic flux was 90+/-6 nmol cm(-2) h(-1) when a 15 mM apomorphine solution was applied in the anodal chamber at a current density of 500 mu Acm(2). At any point in time the contribution of the cell to the transport rate was less than or equal to 3%. The supporting membrane does not contribute significantly to the overall transport rates. Sink conditions are guaranteed at a flow rate greater than or equal to 6.5 ml h(-1). For this new transport cell it can be concluded that the apparentflux that was measured, at validated experimental conditions, is a reliable estimate for the intrinsic flux. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:56:49