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Titolo:
INHIBITION OF IL-12 PRODUCTION BY THALIDOMIDE
Autore:
MOLLER DR; WYSOCKA M; GREENLEE BM; MA XJ; WAHL L; FLOCKHART DA; TRINCHIERI G; KARP CL;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV PULM & CRIT CARE MED,5501 HOPKINS BAYVIEW CIRCLE BALTIMORE MD 21224 JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV INFECT DIS BALTIMORE MD 21224 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOL MICROBIOL & IMMUNOL BALTIMORE MD 21205 NIDR,IMMUNOL LAB,NIH BETHESDA MD 20892 WISTAR INST ANAT & BIOL PHILADELPHIA PA 19104 GEORGETOWN UNIV,MED CTR,DEPT MED & PHARMACOL,DIV CLIN PHARMACOL WASHINGTON DC 20007
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 159, anno: 1997,
pagine: 5157 - 5161
SICI:
0022-1767(1997)159:10<5157:IOIPBT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; VERSUS-HOST DISEASE; BLOOD MONONUCLEAR-CELLS; PULMONARY SARCOIDOSIS; RHEUMATOID-ARTHRITIS; IMMUNE-RESPONSES; INTERLEUKIN-12; CYTOKINE; MICE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Moller et al., "INHIBITION OF IL-12 PRODUCTION BY THALIDOMIDE", The Journal of immunology, 159(10), 1997, pp. 5157-5161

Abstract

The immunomodulatory properties of thalidomide are currently being exploited therapeutically in conditions as diverse as erythema nodosum leprosum, chronic graft-vs-host disease, rheumatoid arthritis, and sarcoidosis. The relevant mechanism of action of thalidomide in these diseases remains unclear, The important role recently ascribed to IL-12, acytokine critical to the development of cellular immune responses, inthe pathogenesis of several of these conditions led us to examine whether thalidomide affects the production of IL-12, Thalidomide potentlysuppressed the production of IL-12 from human PBMC and primary human monocytes in a concentration-dependent manner. Thalidomide-induced inhibition of IL-12 production was additive to that induced by suboptimalinhibiting doses of dexamethasone, and occurred by a mechanism independent of known endogenous inhibitors of IL-12 production. These results suggest that thalidomide may have therapeutic utility in a wide range of immunologic disorders that are characterized by inappropriate cellular immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:42:50