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Titolo:
ANALYSIS OF GRANULOMA-FORMATION IN DOUBLE CYTOKINE-DEFICIENT MICE REVEALS A CENTRAL ROLE FOR IL-10 IN POLARIZING BOTH T-HELPER CELL 1-TYPE AND T-HELPER CELL 2-TYPE CYTOKINE RESPONSES IN-VIVO
Autore:
WYNN TA; MORAWETZ R; SCHARTONKERSTEN T; HIENY S; MORSE HC; KUHN R; MULLER W; CHEEVER AW; SHER A;
Indirizzi:
NIAID,PARASIT DIS LAB,NIH,BLDG 4,ROOM 126,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIAID,IMMUNOPATHOL LAB,IMMUNOBIOL SECT,NIH BETHESDA MD 20892 UNIV COLOGNE,INST GENET D-5000 COLOGNE GERMANY
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 159, anno: 1997,
pagine: 5014 - 5023
SICI:
0022-1767(1997)159:10<5014:AOGIDC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE SCHISTOSOMIASIS-MANSONI; ENDOGENOUS IFN-GAMMA; IN-VIVO; TOXOPLASMA-GONDII; MEDIATED-IMMUNITY; GENE-EXPRESSION; DOWN-REGULATION; TH2 CYTOKINES; TNF-ALPHA; INTERLEUKIN-10;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Wynn et al., "ANALYSIS OF GRANULOMA-FORMATION IN DOUBLE CYTOKINE-DEFICIENT MICE REVEALS A CENTRAL ROLE FOR IL-10 IN POLARIZING BOTH T-HELPER CELL 1-TYPE AND T-HELPER CELL 2-TYPE CYTOKINE RESPONSES IN-VIVO", The Journal of immunology, 159(10), 1997, pp. 5014-5023

Abstract

In response to i.v.-injected eggs of Schistosoma mansoni, normal micedevelop a dominant type 2 response, whereas IL-10-deficient animals generate a mixed type 1/type 2 cytokine profile and show reduced pulmonary granuloma formation. IL-4-deficient mice, while displaying diminished type 2 responses and granulomatous inflammation, also do not fullydefault to a type 1 cytokine profile. Strikingly, mice doubly deficient in IL-4 and IL-10 are completely defective in pulmonary granuloma formation and develop a highly polarized type 1 cytokine pattern. In analogous fashion, mice deficient in both IL-12 and IL-10 generate highly exacerbated type 2 cytokine responses, whereas in wild-type animals,IL-12 depletion minimally effects egg-induced cytokine production. Together, these results argue first that IL-10 is an important endogenous down-regulator of type 2 as well as type 1 cytokine synthesis, and second, that its induction is critical for type 2 response polarizationin vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:08:04