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Titolo:
CHARACTERIZATION OF MURINE CD70, THE LIGAND OF THE TNF RECEPTOR FAMILY MEMBER CD27
Autore:
TESSELAAR K; GRAVESTEIN LA; VANSCHIJNDEL GMW; BORST J; VANLIER RAW;
Indirizzi:
NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL,PLESMANLAAN 125 NL-1066 CX AMSTERDAM NETHERLANDS NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,EXPT & CLIN IMMUNOL LAB NL-1105 AZ AMSTERDAM NETHERLANDS NETHERLANDS CANC INST,DIV CELLULAR BIOCHEM NL-1066 CX AMSTERDAM NETHERLANDS
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 159, anno: 1997,
pagine: 4959 - 4965
SICI:
0022-1767(1997)159:10<4959:COMCTL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; T-CELL ACTIVATION; FAS-LIGAND; B-CELLS; COSTIMULATORY ACTIVITY; OX40 LIGAND; GENE FAMILY; EXPRESSION; IDENTIFICATION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Tesselaar et al., "CHARACTERIZATION OF MURINE CD70, THE LIGAND OF THE TNF RECEPTOR FAMILY MEMBER CD27", The Journal of immunology, 159(10), 1997, pp. 4959-4965

Abstract

Human CD70 (CD27 ligand) is a type II transmembrane glycoprotein belonging to the TNF family. The protein is not expressed on resting lymphocytes, but is rapidly induced on these cells after cellular activation. Importantly, interaction of CD70 with its receptor CD27 gives a costimulatory signal for lymphocyte activation. Whereas CD27 has been molecularly characterized in the mouse, murine CD70 (mCD70) was undefineduntil now. Here, we describe the cDNA cloning and initial characterization of mCD70 and the determination of its gene structure. mCD70 is apolypeptide of 195 amino acids that has 62% homology with its human counterpart. In analogy to human CD70, mCD70 transcript levels are strongly but transiently up-regulated during lymphocyte activation, which is in line with a role for the CD27-CD70 receptor pair early in the immune response. In accordance with the comitogenic activity of mCD27-specific mAb, recombinant mCD70 potently costimulates T cell proliferation, Finally, the mCD70 gene consists of three exons spanning similar to 4 kb of DNA and is localized on chromosome 17.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:22:50