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Titolo:
ONCOSTATIN-M STIMULATES THE EXPRESSION AND RELEASE OF THE IL-6 RECEPTOR IN HUMAN HEPATOMA HEPG2 CELLS
Autore:
CICHY J; ROSEJOHN S; POTEMPA J; PRYJMA J; TRAVIS J;
Indirizzi:
UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL ATHENS GA 30602 UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL ATHENS GA 30602 JAGIELLONIAN UNIV,INST MOL BIOL,DEPT MICROBIOL & IMMUNOL KRAKOW POLAND UNIV MAINZ,DEPT MED MAINZ GERMANY
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 159, anno: 1997,
pagine: 5648 - 5653
SICI:
0022-1767(1997)159:11<5648:OSTEAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE INTERLEUKIN-6 RECEPTOR; MOLECULAR-CLONING; FACTOR-II; CYTOKINES; PLASMA; OVEREXPRESSION; PURIFICATION; FIBROBLASTS; MECHANISM; MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J. Cichy et al., "ONCOSTATIN-M STIMULATES THE EXPRESSION AND RELEASE OF THE IL-6 RECEPTOR IN HUMAN HEPATOMA HEPG2 CELLS", The Journal of immunology, 159(11), 1997, pp. 5648-5653

Abstract

Soluble IL-6R (sIL-6R), which lacks the transmembrane domain, has been suggested to be a potent immunomodulator of IL-6 biologic activity. In this study, the ability of tells of hepatic origin to generate the sIL-6R was investigated, It was found that oncostatin M alone or in combination with the glucocorticoid analogue dexamethasone significantlyup-regulated. IL-6R release, Oncostatin M appeared to generate the sIL-6A primarily through an alternative splicing mechanism. Since sIL-6Ris able to form biologically active complexes with IL-6, the release of the sIL-6R from hepatocytes may be important to sensitize cells lacking the membrane-bound receptor, particularly during an acute phase reaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:18:35