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Titolo:
MOLECULAR-CLONING OF LEUKOTACTIN-1 - A NOVEL HUMAN BETA-CHEMOKINE, A CHEMOATTRACTANT FOR NEUTROPHILS, MONOCYTES, AND LYMPHOCYTES, AND A POTENT AGONIST AT CC-CHEMOKINE RECEPTOR-1 AND RECEPTOR-3
Autore:
YOUN BS; ZHANG SM; LEE EK; PARK DH; BROXMEYER HE; MURPHY PM; LOCATI M; PEASE JE; KIM KK; ANTOL K; KWON BS;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,635 BARNHILL DR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MED INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,WALTHER ONCOL CTR INDIANAPOLIS IN 46202 MOGAM BIOTECHNOL RES INST KYUNGKI DO SOUTH KOREA NIAID,HOST DEF LAB,NIH BETHESDA MD 20892 UNIV SHEFFIELD,KREBS INST,DEPT MOL BIOL & BIOTECHNOL SHEFFIELD S10 2TN S YORKSHIRE ENGLAND ST MARYS COLL,DEPT CHEM PHYS NOTRE DAME IN 46556
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 159, anno: 1997,
pagine: 5201 - 5205
SICI:
0022-1767(1997)159:11<5201:MOL-AN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY FORMATION; IDENTIFICATION; SEQUENCE; GENES; MIP-1-ALPHA; MIP-1-BETA; EXPRESSION; PROTEINS; RANTES; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Youn et al., "MOLECULAR-CLONING OF LEUKOTACTIN-1 - A NOVEL HUMAN BETA-CHEMOKINE, A CHEMOATTRACTANT FOR NEUTROPHILS, MONOCYTES, AND LYMPHOCYTES, AND A POTENT AGONIST AT CC-CHEMOKINE RECEPTOR-1 AND RECEPTOR-3", The Journal of immunology, 159(11), 1997, pp. 5201-5205

Abstract

A new member of human beta-chemokine cDNA was isolated and named leukotactin-1 (Lkn-1). Lkn-1, along with murine macrophage inflammatory protein-related protein-1 and -2, defines a subgroup of beta-chemokines based on two conserved cysteines in addition to the four others conserved in all beta-chemokines. The putative mature Lkn-1 is composed of 92 amino acids with a calculated m.w. of 10,162. The Lkn-1 gene was mapped to human chromosome 17, region q12. Recombinant Lkn-1 was a potentchemoattractant for neutrophils, monocytes, and lymphocytes and induced calcium flux in these cells, Lkn-1 specifically induced calcium flux in CCR1- and CCR3-expressing HOS cell lines. Lkn-1 suppressed colonyformation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. Hence, we have isolated and characterized a human C6 beta-chemokine that is a potent agonist at CCR1 and CCR3 and shows broad biologic activities, including leukocyte chemoattraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:00:02