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Titolo:
RELATIONSHIP BETWEEN APOE, MRI FINDINGS, AND COGNITIVE FUNCTION IN THE CARDIOVASCULAR HEALTH STUDY
Autore:
KULLER LH; SHEMANSKI L; MANOLIO T; HAAN M; FRIED L; BRYAN N; BURKE GL; TRACY R; BHADELIA R;
Indirizzi:
UNIV PITTSBURGH,DEPT EPIDEMIOL,130 DESOTO ST PITTSBURGH PA 15261 CHS COORDINATING CTR SEATTLE WA 00000 NHLBI BETHESDA MD 20892 UNIV CALIF DAVIS DAVIS CA 00000 JOHNS HOPKINS MED INST BALTIMORE MD 21205 WAKE FOREST UNIV,BOWMAN GRAY SCH MED WINSTON SALEM NC 00000 UNIV VERMONT COLCHESTER VT 00000 TUFTS UNIV,NEW ENGLAND MED CTR,CHS ULTRASOUND LAB BOSTON MA 02111
Titolo Testata:
Stroke
fascicolo: 2, volume: 29, anno: 1998,
pagine: 388 - 398
SICI:
0039-2499(1998)29:2<388:RBAMFA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E ALLELES; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; EPSILON-4 ALLELE; ELDERLY PEOPLE; RISK-FACTORS; EDUCATION; IMPAIRMENT; STROKE; ASSOCIATION;
Keywords:
APOLIPOPROTEINS; DEMENTIA; MAGNETIC RESONANCE IMAGING; STROKE; VASCULAR DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
L.H. Kuller et al., "RELATIONSHIP BETWEEN APOE, MRI FINDINGS, AND COGNITIVE FUNCTION IN THE CARDIOVASCULAR HEALTH STUDY", Stroke, 29(2), 1998, pp. 388-398

Abstract

Background and Purpose-We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores. Methods-The relationship between age, education, ApoE genotype, MRI examination of the brain,subclinical and clinical cardiovascular disease, and low (<80) score on the Modified Mini-Mental State Examination (3MSE, as modified by Teng and Chui) was evaluated for 3469 black and white participants in the Cardiovascular Health Study (CHS) in years 5 and 6 of the study. Theparticipants were followed for up to 3 years. Results-The prevalence of scores <80 in years 5 and 6 of the CHS was 8.2% for participants without and 20.4% for those with prior history of stroke. Age, race, andeducation were important determinants of low 3MSE scores, The prevalence of ApoE-4 (odds ratio [OR], 1.6 [1.1 to 2.1]) was directly relatedto scores <80, as was high ventricular volume (OR, 1.6 [1.2 to 2.3]),high white matter grade (OR, 1.4 [1.1 to 1.9]), and infarctlike lesions (OR, 1.6 [1.2 to 2.1]) on the MRI in the multivariate analysis. A five-point or greater decline in scores over up to 3 years was more often observed for participants with low 3MSE scores at year 5, at older ages, with lower education, and experiencing incident stroke (OR, 3.6 [1.2 to 10.6]), ApoE-4 genotype (OR, 1.8 [1.4 to 2.3]), and with MRI findings of high ventricular volume (OR, 2.0 [1.5 to 2.7]), and infarctlike lesions (OR, 1.2 [0.9 to 1.5]). Conclusions-These results demonstrate that vascular changes on MRI, measures of brain atrophy, AgoE-4, and age, education, and race are associated with low cognitive scores among older individuals. The MRI of the brain provides valuable information related to cognitive tests and decline over time. The potential exists for using MRI measurements to identify high-risk individuals for dementia and to test potential interventions to reduce the risk of dementia.

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Documento generato il 01/12/20 alle ore 07:39:15