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Titolo:
LEARNING AND MEMORY IN THE SAMP8 MOUSE
Autore:
FLOOD JF; MORLEY JE;
Indirizzi:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,151-JC,915 N GRAND BLVD ST LOUIS MO 63106 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN ST LOUIS MO 63106 ST LOUIS UNIV,SCH MED,DEPT INTERNAL MED,DIV GERIATR MED ST LOUIS MO 63104
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 1, volume: 22, anno: 1998,
pagine: 1 - 20
SICI:
0149-7634(1998)22:1<1:LAMITS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENESCENCE-ACCELERATED MOUSE; AGE-RELATED-CHANGES; HIPPOCAMPAL THETA-RHYTHM; AMYLOID BETA-PROTEIN; CHOLINERGIC DRUG-COMBINATIONS; ALZHEIMERS-DISEASE; BRAIN-STEM; INHIBITORY INTERNEURONS; GRANULAR STRUCTURES; PRECURSOR PROTEIN;
Keywords:
ACETYLCHOLINE; AGING; DEMENTIA; GABA; GLUTAMATE; HIPPOCAMPUS; LEARNING; MEMORY; MICE; SAM; SEPTUM; SEROTONIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
97
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Flood e J.E. Morley, "LEARNING AND MEMORY IN THE SAMP8 MOUSE", Neuroscience and biobehavioral reviews, 22(1), 1998, pp. 1-20

Abstract

The SAMPs (P8) mouse strain develops deficits in learning and memory relatively early in its lifespan. This review provides an overview of the age-related changes that occur in P8 mice. Behavioral studies withPs mice show impaired acquisition and retention as early as 4 months of age. Deficits in acquisition and retention occur with both aversiveand appetitive training tasks. Anatomical studies have detected a number of age-related changes that occur in the central nervous system ofP8 mice. The age-related increase in amyloid beta protein is well correlated with the age-related decline in learning and memory. Antibody to amyloid beta protein injected prior to training alleviated impairedacquisition and retention, whereas post-training injections alleviated retention deficits in older P8 mice. Biochemical studies have detected numerous age-related changes with reduced NMDA receptor activity most closely related to impaired learning and memory in P8 mice. Pharmacological studies have found age-related functional changes in the ability of drugs to improve memory processing in P8 mice in the septum andthe hippocampus. The specific pattern of pharmacological changes and the inferred change in neurotransmitter activity suggest that age-related impairment in memory processing may be due to impaired septohippocampal interactions. The proposal that P8 mice may be a useful model for studying the early phases of age-related dementia of the Alzheimer type, while still requiring considerable study, seems reasonable. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:51:13