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Titolo:
SUPPRESSION OF ANAPHYLACTIC REACTION IN MURINE BY SIEGESBECKIA-PUBESCENS
Autore:
KIM HM; KIM CY; KWON MH; SHIN TY; LEE EJ;
Indirizzi:
WONKWANG UNIV,COLL PHARM CHONJU 570749 SOUTH KOREA WONKWANG UNIV,COLL ORIENTAL MED CHONJU 570749 SOUTH KOREA WOOSUK UNIV,COLL PHARM CHONJU 565800 SOUTH KOREA
Titolo Testata:
Archives of pharmacal research
fascicolo: 2, volume: 20, anno: 1997,
pagine: 122 - 127
SICI:
0253-6269(1997)20:2<122:SOARIM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELLS; IMMUNOGLOBULIN-E; HIGH-AFFINITY; SUBSTANCE-P; HISTAMINE; RECEPTOR; RELEASE; COMPOUND-48/80; ACTIVATION; PROTEINS;
Keywords:
SIEGESBECKIA PUBESCENS; SYSTEMIC ANAPHYLAXIS; PASSIVE CUTANEOUS ANAPHYLAXIS; HISTAMINE; MAST CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Kim et al., "SUPPRESSION OF ANAPHYLACTIC REACTION IN MURINE BY SIEGESBECKIA-PUBESCENS", Archives of pharmacal research, 20(2), 1997, pp. 122-127

Abstract

The aqueous extract of Siegesbeckia pubescens (SPAE) inhibited compound 48/80-induced systemic anaphylaxis 100% with the dose of 1.0, 0.5 mg/g body weight (BW) at 1 h before or 5 min, 10 min after intraperitoneal injection of compound 48/80. The passive cutaneous anaphylaxis (PCA) reaction also inhibited to 78.5% by oral administration of SPAE (1.0 mg/g BW). When SPAE pretreated on mice at concentrations ranging from 0.0001 to 1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SPAE (100-800 mu g/ml) dose-dependently inhibited the histamine release from peritoneal mast cells (RPMC) by compound 48/80 (5 mu g/ml). Analysis by microscopic appearance observation revealed that SPAE (500 mu g/ml) stabilized the RPMC membrane. Therefore, these findings indicate that SPAE inhibits anaphylactic reactions through stabilization of mast cell membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:12:44