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Titolo:
PHOTORECEPTOR RHODOPSIN - STRUCTURAL AND CONFORMATIONAL STUDY OF ITS CHROMOPHORE 11-CIS RETINAL IN ORIENTED MEMBRANES BY DEUTERIUM SOLID-STATE NMR
Autore:
GROBNER G; CHOI G; BURNETT IJ; GLAUBITZ C; VERDEGEM PJE; LUGTENBURG J; WATTS A;
Indirizzi:
UNIV OXFORD,DEPT BIOCHEM,BIOMEMBRANE STRUCT UNIT,S PARKS RD OXFORD OX1 3QU ENGLAND UNIV OXFORD,DEPT BIOCHEM,BIOMEMBRANE STRUCT UNIT OXFORD OX1 3QU ENGLAND LEIDEN UNIV,LEIDEN INST CHEM NL-2300 RA LEIDEN NETHERLANDS
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 422, anno: 1998,
pagine: 201 - 204
SICI:
0014-5793(1998)422:2<201:PR-SAC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; PROTEIN-STRUCTURE; BOVINE RHODOPSIN; HEAD GROUPS; BACTERIORHODOPSIN; BILAYER; GRAMICIDIN; RECEPTORS; DYNAMICS;
Keywords:
MEMBRANE PROTEIN; RHODOPSIN; NMR, SOLID STATE H-2-; 7 TMD GTP COUPLED RECEPTOR; RETINAL STRUCTURE; LIGAND-RECEPTOR INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G. Grobner et al., "PHOTORECEPTOR RHODOPSIN - STRUCTURAL AND CONFORMATIONAL STUDY OF ITS CHROMOPHORE 11-CIS RETINAL IN ORIENTED MEMBRANES BY DEUTERIUM SOLID-STATE NMR", FEBS letters, 422(2), 1998, pp. 201-204

Abstract

Rhodopsin is the retinal photoreceptor responsible for visual signal transduction. To determine the orientation and conformation of retinalwithin the binding pocket of this membrane bound receptor, an ab initio solid state H-2 NMR approach was used. Bovine rhodopsin containing Il-cis retinal, specifically deuterated at its methyl groups at the C-19 or C-20 position, was uniaxially oriented in DMPC bilayers. Integrity of the membranes and quality of alignment were monitored by P-31 NMR. Analysis of the obtained H-2 NMR spectra provided angles for the individual labelled chemical bond vectors leading to an overall picture for the three dimensional structure of the polyene chain of the chromophore in the protein binding pocket around the Schiff base attachment site. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:53:10