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Titolo:
ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES IN INFLAMMATORY BOWEL-DISEASE
Autore:
PAPO M; QUER JC; PASTOR RM; GARCIAPARDO G; OLONA M; PRATS E; MIRAPEIX E; RODRIGUEZ R; RICHART C;
Indirizzi:
UNIV ROVIRA & VIRGILI,HOSP JOAN XXIII,SECC APARATO DIGEST,SERV BIOQUIM,MALLAFRE GUASCH 4 TARRAGONA 43007 SPAIN UNIV ROVIRA & VIRGILI,HOSP JOAN XXIII,MED INTERNA SERV TARRAGONA 43007 SPAIN UNIV ROVIRA & VIRGILI,HOSP JOAN XXIII,SERV MED PREVENT TARRAGONA 43007 SPAIN HOSP ST JOAN,MED INTERNA SERV REUS SPAIN HOSP CLIN BARCELONA,SERV NEFROL BARCELONA SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 1, volume: 110, anno: 1998,
pagine: 11 - 15
SICI:
0025-7753(1998)110:1<11:ACAIIB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
SPA
Soggetto:
PRIMARY SCLEROSING CHOLANGITIS; ULCERATIVE-COLITIS PATIENTS; NEUTROPHIL AUTOANTIBODIES; ANTIBODIES ANCA; DIAGNOSTIC ROLE; P-ANCA; SPECIFICITY; PREVALENCE; MARKER; GLOMERULONEPHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M. Papo et al., "ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES IN INFLAMMATORY BOWEL-DISEASE", Medicina Clinica, 110(1), 1998, pp. 11-15

Abstract

BACKGROUND: The aim of the present study was to determine the prevalence and diagnostic usefulness of antineutrophil cytoplasmic antibodies(ANCA) in a Spanish population of patients with inflammatory bowel disease from the province of Tarragona, PATIENTS AND METHODS: One hundred and fifty-six sera obtained from 116 patients with inflammatory bowel disease (75 ulcerative colitis and 41 Crohn's disease) and 40 healthy controls were tested using an indirect immunofluorescence assay. RESULTS: ANCA were detected in 65% of patients with ulcerative colitis but in only 12% of patients with Crohn's disease (p < 0.01), and 2.5% ofcontrol subjects (p < 0.01), The overall sensitivity of the test for the diagnosis of ulcerative colitis was 65% with a specificity of 88% and a positive predictive value of 91%. Among patients with ulcerativecolitis there was no relationship between the presence or titre of ANCA and the duration, the clinical course, the extent, the disease activity or the nedd for medical treatment. CONCLUSIONS: In the populationstudied, ANCA occur more commonly in ulcerative colitis than in Crohn's disease, as reported in other populations. Their determination in patients with inflammatory bower disease may be useful to differentiateulcerative colitis from Crohn's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:00:29