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Titolo:
CUTTING EDGE - P21-ACTIVATED KINASE (PAK) IS REQUIRED FOR FAS-INDUCEDJNK ACTIVATION IN JURKAT CELLS
Autore:
RUDEL T; ZENKE FT; CHUANG TH; BOKOCH GM;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,IMM14,10550 N TORREY PINES RD LAJOLLA CA 92037 SCRIPPS CLIN & RES INST,DEPT IMMUNOL LA JOLLA CA 92037 SCRIPPS CLIN & RES INST,DEPT CELL BIOL LA JOLLA CA 00000
Titolo Testata:
The Journal of immunology
fascicolo: 1, volume: 160, anno: 1998,
pagine: 7 - 11
SICI:
0022-1767(1998)160:1<7:CE-PK(>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; N-TERMINAL KINASE; PROTEIN-KINASE; MEDIATED APOPTOSIS; ICE-LIKE; DEATH; STRESS; CERAMIDE; CDC42; DOWNSTREAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
T. Rudel et al., "CUTTING EDGE - P21-ACTIVATED KINASE (PAK) IS REQUIRED FOR FAS-INDUCEDJNK ACTIVATION IN JURKAT CELLS", The Journal of immunology, 160(1), 1998, pp. 7-11

Abstract

The process of apoptosis is a critical component of normal immune system development and homeostasis, and in many cells this involves signaling through the c-Jun amino terminal kinase (JNK) pathway. In jurkat T cells, Fas-induced JNK activity is dependent upon activation of the caspase cascades known to be central components of the apoptotic program. We show in Jurkat cell lines expressing a dominant negative PAK construct that PAK signaling is necessary for JNK activation in responseto Fas receptor cross-linking, Inhibition of JNK activation induced by Fas does not impair cell death as assessed by DNA fragmentation, However, expression of the catalytically active C terminus of PAK2, whichis generated through caspase action during Fas-mediated apoptosis, induces Jurkat cell apoptosis, We conclude that PAK activity resulting from caspase-mediated cleavage is a necessary component of JNK activation induced by Fas receptor signaling and that PAK2 can contribute to the induction of cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 11:38:29