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Titolo:
CONGENITAL UNDESCENDED TESTES IN NEONATAL PIGS AND THE EFFECT OF EXOGENOUS CALCITONIN-GENE-RELATED PEPTIDE
Autore:
HUTSON JM; WATTS LM; FARMER PJ;
Indirizzi:
ROYAL CHILDRENS HOSP,RES FDN,F DOUGLAS STEPHENS SURG RES LAB MELBOURNE VIC AUSTRALIA
Titolo Testata:
The Journal of urology
fascicolo: 3, volume: 159, anno: 1998,
pagine: 1025 - 1028
SICI:
0022-5347(1998)159:3<1025:CUTINP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; GUBERNACULUM; FETUS; CRYPTORCHIDISM; CELLS; RAT;
Keywords:
CRYPTORCHIDISM; CALCITONIN GENE-RELATED PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Hutson et al., "CONGENITAL UNDESCENDED TESTES IN NEONATAL PIGS AND THE EFFECT OF EXOGENOUS CALCITONIN-GENE-RELATED PEPTIDE", The Journal of urology, 159(3), 1998, pp. 1025-1028

Abstract

Purpose: We investigated the neonatal piglet as a possible animal model for cryptorchidism and to determine whether calcitonin gene-relatedpeptide (CGRP), which has been proposed to regulate inguinoscrotal testicular descent, could induce testicular descent in piglets with congenital cryptorchidism. Materials and Methods: We examined 38 cryptorchid piglets to document the anatomy in 8 and to investigate the role ofCGRP in 30. The 2-week-old piglets were allocated randomly to receivea mini-osmotic pump containing CGRP at various concentrations or phosphate buffered saline. The pump was inserted surgically into the ipsilateral scrotum, with the contents blinded to the surgeon. The positions of the testes, pump and anatomical landmarks were measured and photographed. The pigs were sacrificed and dissected 2 weeks later, and thepositions were remeasured and photographed. The testes were examined histologically. Results: The 3 variants of cryptorchidism observed were intra-abdominal in 20 cases, inguinal in 9 and lateral inguinal ectopic in 9. CGRP had no effect on intra-abdominal or ectopic testes. In contrast, for inguinal testes exogenous CGRP caused a slight but significant 10 +/- 7.9 mm. descent towards the pump in 5 cases compared to -2.9 +/- 5.8 mm. in 4 controls. Conclusions: Exogenous CGRP stimulatedmigration of inguinal testes that had been arrested in the line of descent while ectopic testes did not respond. These results support a role for CGRP in testicular descent and suggest that a slow release depot preparation might be useful as a possible treatment in some forms ofcryptorchidism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:32:13