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Titolo:
ANTICARCINOGENIC ACTIVITY OF 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE, ANACTIVE ANTIPROLIFERATIVE PRINCIPAL OF WASABI (EUTREMA-WASABI MAXIM.)
Autore:
FUKE Y; HAGA Y; ONO H; NOMURA T; RYOYAMA K;
Indirizzi:
TOKYO METROPOLITAN COLL,DEPT FOOD SCI & HUMAN NUTR TOKYO 196 JAPAN SKYLARK FOOD SCI INST,MIHAMA KU CHIBA 26101 JAPAN KANAZAWA UNIV,CANC RES INST KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Cytotechnology
fascicolo: 1-3, volume: 25, anno: 1997,
pagine: 197 - 203
SICI:
0920-9069(1997)25:1-3<197:AAO6IA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; STOMACH-CANCER CELLS; PROTECTIVE ENZYMES; INDUCTION; MECHANISMS; REDUCTASE; INDUCER; GROWTH;
Keywords:
ANTICARCINOGENIC ACTIVITY; ISOTHIOCYANATE; WASABI;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y. Fuke et al., "ANTICARCINOGENIC ACTIVITY OF 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE, ANACTIVE ANTIPROLIFERATIVE PRINCIPAL OF WASABI (EUTREMA-WASABI MAXIM.)", Cytotechnology, 25(1-3), 1997, pp. 197-203

Abstract

Synthetic 4-methylsulfinylhexyl isothiocyanate (MITC)(a potent inducer of phase 2 detoxification enzymes from broccoli) and 6-MITC(a potentanti-proliferative principal from wasabi) slightly inhibited the induction of mouse skin tumor in a two-stage process of carcinogenesis (initiator, 9,10-dimethyl-1,2-benzanthracene; promotor,12-o-tetradecanoylphorbol-13-acetate), but the effect was not significant. Both compounds, however, significantly inhibited the mutation of skin resulting from topical applications of the carcinogens. When a murine hepatoma cellline, Hepa 1c1c7, was treated with 2-, 4-, 6- and 8-MITCs, they augmented the induction of its quinone reductase, one of the phase 2 detoxification enzymes in a concentration dependent manner, and the 4- and 6-MITCs were much more potent on the reduction of the enzyme than the 2- and 8-MITCs. All 2-, 4-, 6- and 8-MITCs suppressed the growth of murine tumor cells, their suppressive activities being proportional to the length of their methyl residue. They were also cytotoxic to mouse peritoneal exudate macrophages which were not proliferating in vitro, indicating that the cellular targets of isothiocyanate may not be dependent upon the cell cycle. In addition, all the 2-, 4-, 6- and 8-MITCs inhibited the production of nitric oxide (a potent radical carcinogen) by peritoneal macrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:04:28