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Titolo:
DISCRIMINATIVE STIMULUS EFFECTS OF BUPRENORPHINE IN THE RAT
Autore:
HOLTZMAN SG;
Indirizzi:
EMORY UNIV,SCH MED,DEPT PHARMACOL ATLANTA GA 30322
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 130, anno: 1997,
pagine: 292 - 299
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGONIST-ANTAGONIST OPIOIDS; DIFFERENTIAL SENSITIVITY; OPIATE AGONISTS; MORPHINE-LIKE; MU; HYDROMORPHONE; PHARMACOLOGY; DEPENDENCE; METHADONE; EFFICACY;
Keywords:
DRUG DISCRIMINATION; BUPRENORPHINE; MORPHINE; OPIOID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Holtzman, "DISCRIMINATIVE STIMULUS EFFECTS OF BUPRENORPHINE IN THE RAT", Psychopharmacology, 130(3), 1997, pp. 292-299

Abstract

Buprenorphine, a potent ''low efficacy'' or ''partial'' morphine-likeopioid agonist, has morphine-like discriminative effects in animals and humans discriminating morphine or a related drug. The purpose of the present study was to characterize further the discriminative effectsof buprenorphine in subjects trained to discriminate buprenorphine itself. Rats trained to discriminate between SC injections of saline andeither 0.03 or 0.1 mg/kg buprenorphine generalized completely to morphine and to other morphine-like agonists. These drugs were approximately 3 times more potent in the rats trained with 0.03 mg/kg buprenorphine than in those trained with 0.1 mg/kg; however, the potency of buprenorphine itself did not differ significantly between groups. Indicative of efficacy differences among mixed-action opioids, rats discriminating 0.03 mg/kg buprenorphine generalized completely to butorphanol andpentazocine and partially to nalbuphine, whereas those discriminating0.1 mg/kg generalized completely to butorphanol, partially to pentazocine, and little to nalbuphine. Stimulus control of behavior by 0.1 mg/kg buprenorphine was blocked surmountably by low doses of antagonists, stereoselective, and pharmacologically selective. These results are consistent with those of other studies showing that the discriminativeeffects of buprenorphine are morphine-like and mediated by the mu-opioid receptor, and extend the conditions under which this has been demonstrated to stimulus control maintained by buprenorphine itself.

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Documento generato il 04/12/20 alle ore 21:36:46