Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITION OF 5-HT CELL FIRING IN THE DRN BY NON SELECTIVE 5-HT REUPTAKE INHIBITORS - STUDIES ON THE ROLE OF 5-HT1A AUTORECEPTORS AND NORADRENERGIC MECHANISMS
Autore:
GARTSIDE SE; UMBERS V; SHARP T;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,WOODSTOCK RD OXFORD OX2 6HE ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 130, anno: 1997,
pagine: 261 - 268
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; SEROTONERGIC NEURONS; ANTIDEPRESSANT DRUGS; MAJOR DEPRESSION; FRONTAL-CORTEX; RAT-BRAIN; 5-HYDROXYTRYPTAMINE; PAROXETINE; ALPHA(1)-ADRENOCEPTORS; HYPERPOLARIZATION;
Keywords:
5-HT CELL FIRING; TRICYCLIC ANTIDEPRESSANTS (TCAS); SEROTONIN AND NORADRENALINE REUPTAKE INHIBITORS (SNRIS); VENLAFAXINE; SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS); 5-HT1A RECEPTORS; ALPHA(1) ADRENOCEPTORS; DORSAL RAPHE NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Gartside et al., "INHIBITION OF 5-HT CELL FIRING IN THE DRN BY NON SELECTIVE 5-HT REUPTAKE INHIBITORS - STUDIES ON THE ROLE OF 5-HT1A AUTORECEPTORS AND NORADRENERGIC MECHANISMS", Psychopharmacology, 130(3), 1997, pp. 261-268

Abstract

Improved clinical antidepressant efficacy may result if the acute inhibition of 5-HT cell firing induced by antidepressants is prevented. Here we examined whether inhibition of 5-HT cell firing by non-selective 5-HT uptake inhibiting antidepressant drugs is reversed by a selective 5-HT1A receptor antagonist. In addition, we examined whether concomitant blockade of NA uptake offsets the inhibition of 5-HT cell firingresulting from 5-HT uptake blockade. Antidepressants which block 5-HTuptake (paroxetine, clomipramine, amitriptyline, venlafaxine), all caused dose-dependent and complete inhibition of 5-HT cell firing. Desipramine, a selective NA uptake blocker, caused a slight reduction in firing. The selective 5-HT1A receptor antagonist, WAY 100635, reversed the inhibition of 5-HT cell firing induced by clomipramine, amitriptyline, venlafaxine, and paroxetine, but not that induced by the alpha(1) adrenoceptor antagonist, prazosin. Desipramine, at a dose which increased extracellular NA in the DRN, reversed the effect of prazosin but did not alter the ability of paroxetine to inhibit 5-HT cell firing. Our data indicate that antidepressant drugs with 5-HT uptake blocking properties inhibit 5-HT cell firing via activation of 5-HT1A autoreceptors, and do so irrespective of their effects on NA uptake. These data are discussed in relation to the application of 5-HT1A receptor antagonists to enhance the clinical efficacy of antidepressant drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:54:48