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Titolo:
A MODEL OF NA-K-2CL COTRANSPORT BASED ON ORDERED ION-BINDING AND GLIDE SYMMETRY
Autore:
LYTLE C; MCMANUS TJ; HAAS M;
Indirizzi:
UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521 DUKE UNIV,MED CTR,DEPT CELL BIOL DURHAM NC 27710
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 2, volume: 43, anno: 1998,
pagine: 299 - 309
SICI:
0363-6143(1998)43:2<299:AMONCB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCK RED-CELLS; OUABAIN-INSENSITIVE SALT; K-CL COTRANSPORT; HUMAN-ERYTHROCYTES; CATION-TRANSPORT; WATER MOVEMENTS; CO-TRANSPORT; NA; POTASSIUM; STOICHIOMETRY;
Keywords:
AVIAN RED BLOOD CELLS; TRANSPORT KINETICS; BUMETANIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C. Lytle et al., "A MODEL OF NA-K-2CL COTRANSPORT BASED ON ORDERED ION-BINDING AND GLIDE SYMMETRY", American journal of physiology. Cell physiology, 43(2), 1998, pp. 299-309

Abstract

In the duck red blood cell, Na-K-2Cl cotransport exhibits two modes of ion movement: net cotransport and obligate cation exchange. In high-K cells, the predominant exchange is WK (or K/Rb). In high-Na cells, it becomes Na/Na (or Na/Li). Both represent partial reactions in which a fully loaded carrier releases part of its cargo, rebinds fresh ions,and returns back across the membrane fully loaded. Net cotransport occurs when the carrier unloads completely and returns empty. This mode has a fixed stoichiometry of 1Na:1K:2Cl under all conditions tested. The ion requirements of the two exchanges differ: K/K exchange requiresonly K and Cl outside but all three ions inside. Na/Na exchange requires all three ions outside but only Na inside. We propose a simple model in which the carrier can only move when either fully loaded or completely empty and in which the ions bind in a strictly ordered sequence. For example, externally, a Na binds first and then a Cl, followed bya K and a second Cl. Internally, the first on is the first off (glidesymmetry), so the Na is released first and then the first Cl, followed by the K and finally by the second Cl. Only then can the empty form return to the outside to start a new cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:31:09