Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTI-RNA POLYMERASES AND OTHER AUTOANTIBODY SPECIFICITIES IN SYSTEMIC-SCLEROSIS
Autore:
BUNN CC; DENTON CP; SHIWEN X; KNIGHT C; BLACK CM;
Indirizzi:
ROYAL FREE HOSP,DEPT CLIN IMMUNOL,POND ST LONDON NW3 2QG ENGLAND ROYAL FREE HOSP,DEPT RHEUMATOL LONDON NW3 2QG ENGLAND
Titolo Testata:
British journal of rheumatology
fascicolo: 1, volume: 37, anno: 1998,
pagine: 15 - 20
SICI:
0263-7103(1998)37:1<15:APAOAS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHORYLATED IIO FORM; LUPUS-ERYTHEMATOSUS; TOPOISOMERASE-I; SCLERODERMA; ASSOCIATION; IDENTIFICATION; ANTINUCLEAR; ANTIBODIES; PROGNOSIS; SERA;
Keywords:
SYSTEMIC SCLEROSIS; AUTOANTIBODIES; RNA POLYMERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Bunn et al., "ANTI-RNA POLYMERASES AND OTHER AUTOANTIBODY SPECIFICITIES IN SYSTEMIC-SCLEROSIS", British journal of rheumatology, 37(1), 1998, pp. 15-20

Abstract

Sera from 735 patients with systemic sclerosis were classified according to antinuclear antibody (ANA) pattern as follows: centromere (25%), homogeneous (26%), fine speckled (21%), fine speckled with nucleolar(14%), coarse speckled (7%), nucleolar only (3%) and cytoplasmic only(3%). Immunoprecipitations using S-35-labelled HeLa cell antigen extract were performed using sera from 374 of these patients to detect thesystemic sclerosis-specific antibodies to RNA polymerases I and III. The sera were selected to represent each ANA group, but focused on those giving fine speckled nucleoplasmic staining (with or without nucleolar staining) where all 86 sera positive for these antibodies were concentrated. Immunoprecipitates from a further 93 sera from patients with ANA-positive autoimmune diseases other than systemic sclerosis did not precipitate RNA polymerases. In addition, all sera were tested for antibodies to the extractable nuclear antigens topoisomerase I, nRNP, Ro, La and PM-Scl. Sera positive for antibodies to these antigens gaveclear correlations with ANA patterns but, of the examples tested, none contained antibodies precipitating RNA polymerase I or III. Thus, sera containing antibodies to RNA polymerases I and III were exclusive of both anticentromere and anti-topoisomerase I, and formed a major serological subgroup (11.7%). Clinically, 77% were patients with diffuse cutaneous disease reflected by higher skin scores and a significantly higher incidence of renal involvement (33%) than patients with antibodies to topoisomerase I (3%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:25:29