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Titolo:
HEMODYNAMIC-EFFECTS AND PHARMACOKINETICS OF ORAL D-NEBIVOLOL AND L-NEBIVOLOL IN HYPERTENSIVE PATIENTS
Autore:
HIMMELMANN A; HEDNER T; SNOECK E; LUNDGREN B; HEDNER J;
Indirizzi:
BERLIN CHEM AG,GLIENICKER WEG 125 D-12489 BERLIN GERMANY STAHLGRENSKA UNIV KLIN,KLIN PHARMAKOL ABT GOTHENBURG SWEDEN
Titolo Testata:
Perfusion
fascicolo: 1, volume: 11, anno: 1998,
pagine: 41 - 48
SICI:
0935-0020(1998)11:1<41:HAPOOD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
GER
Soggetto:
BETA-BLOCKER NEBIVOLOL; DOUBLE-BLIND; ANTIHYPERTENSIVE THERAPY; DILATED CARDIOMYOPATHY; NITRIC-OXIDE; PHARMACOLOGY; ATENOLOL; CARVEDILOL; QUALITY; LIFE;
Keywords:
NEBIVOLOL; HYPERTENSION; D,L-ENANTIOMERS; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Himmelmann et al., "HEMODYNAMIC-EFFECTS AND PHARMACOKINETICS OF ORAL D-NEBIVOLOL AND L-NEBIVOLOL IN HYPERTENSIVE PATIENTS", Perfusion, 11(1), 1998, pp. 41-48

Abstract

Objective: Nebivolol is a selective beta(1)-adrenergic receptor blocker possessing an ancillary vasodilating effect, The objective of the present study was to study the haemodynamic and pharmacokinetic properties of nebivolol 5 mg once daily in a double-blind, placebo-controlledcross-over study. Methods: Fifteen patients, 12 men and 3 women, withessential hypertension were investigated, Blood pressure and peripheral circulation were determined after acute oral nebivolol administration, 5 mg daily, and after 4 weeks treatment. Results: The acute effecton blood pressure upon single dosing was weak and non-significant. After 4 weeks both systolic blood pressure (152 vs 163 mmHg) and diastolic blood pressure (89 vs 97 mmHg) were significantly reduced after nebivolol treatment as compared to placebo. Following the first dose the venous volume was higher on placebo (5.88 ml X 100 ml(-1) tissue) as compared to active nebivolol treatment (5.17 ml X 100 ml(-1) tissue), while there were no statistically significant differences with regard to venous plethysmographic findings after one month on placebo (5.53 mlX 100 ml(-1) tissue) or on active treatment (5.97 ml X 100 ml(-1) tissue). Calculated peripheral resistance did not differ between active treatment (617 units) or placebo (548 units) after the first dose, whereas it was significantly lowered after 4 weeks of nebivolol treatment (483 units) as compared to placebo (593 units). Conclusions: Oral nebivolol 5 mg once daily lowered blood pressure and heart rate during steady state compared to placebo, Moreover, venous volume was reduced during acute but not steady state dosing, while peripheral resistance wasunaffected in the acute phase but reduced during steady state. Plasmaconcentrations of the separate enantiomers plus hydroxylated metabolites after the first and last dose in hypertensive patients were similar to those in healthy subjects.

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Documento generato il 18/09/20 alle ore 18:41:19