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Titolo:
EFFECTS OF SILIBININ AND OF A SYNTHETIC ANALOG ON ISOLATED RAT HEPATIC STELLATE CELLS AND MYOFIBROBLASTS
Autore:
FUCHS EC; WEYHENMEYER R; WEINER OH;
Indirizzi:
MADAUS AG,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY UNIV MARBURG,DEPT CLIN CHEM MARBURG GERMANY MAX PLANCK INST BIOCHEM,DEPT CELL BIOL MARTINSRIED GERMANY
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 12, volume: 47, anno: 1997,
pagine: 1383 - 1387
SICI:
0004-4172(1997)47:12<1383:EOSAOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; INTERFERON-GAMMA; MESSENGER-RNA; LIVER-CELLS; PROTEOGLYCAN; EXPRESSION; SEQUENCES; FIBROSIS; PROTEINS; SULFATE;
Keywords:
HEPATIC STELLATE CELLS; MYOFIBROBLASTS; NH40 X HCL 2-(3-PYRIDYL)-4-H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE; SILIBININ; TRANSFORMING GROWTH FACTOR BETA;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.C. Fuchs et al., "EFFECTS OF SILIBININ AND OF A SYNTHETIC ANALOG ON ISOLATED RAT HEPATIC STELLATE CELLS AND MYOFIBROBLASTS", Arzneimittel-Forschung, 47(12), 1997, pp. 1383-1387

Abstract

Hepatic stellate cells and the derived myofibroblasts play a central pathogenic role in liver fibrogenesis. In order to identify the still unknown hepatoprotective properties of the flavonoid silibinin and therelated pyridylchromone NH40 x HCl (2-(3-pyridyl)-4-H-1-benzopyran-4-one hydrochloride), their effects on isolated rat hepatic stellate cells and derived myofibroblasts were determined. Concentrations of 10(-4) mol/l silibinin reduced the proliferation of freshly isolated rat hepatic stellate cells by about 75 %, but had no detectable effect on their viability, morphology and their cytoskeletal architecture. It reduced the transformation towards myofibroblasts and down-regulated the gene expression of extracellular matrix components and the profibrogenic transforming growth factor beta. Whereas silibinin concentrations higher than 10(-4) mol/l were toxic, lower concentrations had no effectson the proliferation and transformation behavior. Although 10(-4) mol/l NH40 x HCl reduced the proliferation rate by about 50 %, this substance had no significant effect on the transformation process. The results indicate that one important aspect of the potential antifibrotic properties of silibinin might be the inhibition of hepatic stellate cell proliferation and transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:45:11