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Titolo:
PERIPHERAL AND CENTRAL HYPEREXCITABILITY - DIFFERENTIAL SIGNS AND SYMPTOMS IN PERSISTENT PAIN
Autore:
CODERRE TJ; KATZ J;
Indirizzi:
CLIN RES INST MONTREAL,PAIN MECHANISMS LAB,110 PINE AVE W MONTREAL PQH2W 1R7 CANADA UNIV MONTREAL,CTR RECH SCI NEUROL MONTREAL PQ H3C 3J7 CANADA UNIV MONTREAL,DEPT MED MONTREAL PQ H3C 3J7 CANADA MCGILL UNIV,DEPT PSYCHOL MONTREAL PQ H2W 1R7 CANADA TORONTO HOSP,DEPT PSYCHOL TORONTO ON CANADA TORONTO HOSP,ACUTE PAIN RES UNIT TORONTO ON CANADA UNIV TORONTO,DEPT BEHAV SCI TORONTO ON M5S 2C4 CANADA UNIV TORONTO,DEPT ANAESTHESIA TORONTO ON M5S 2C4 CANADA
Titolo Testata:
Behavioral and brain sciences
fascicolo: 3, volume: 20, anno: 1997,
pagine: 404 -
SICI:
0140-525X(1997)20:3<404:PACH-D>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; SPINOTHALAMIC TRACT NEURONS; EXCITATORY AMINO-ACIDS; SCIATIC-NERVE INJURY; PHANTOM LIMB PAIN; RAT SPINAL-CORD; INFLUENCE POSTOPERATIVE ANALGESIA; NOXIOUS MECHANICAL STIMULATION; FORMALIN-INDUCED ACTIVITY; LUMBAR EPIDURAL BLOCKADE;
Keywords:
HYPERALGESIA; NEUROGENIC INFLAMMATION; NEUROPATHIC PAIN; NOCICEPTION; PHANTOM LIMB PAIN; PLASTICITY; POSTOPERATIVE PAIN; PREEMPTIVE ANALGESIA; REFERRED PAIN; SENSITIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
272
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Coderre e J. Katz, "PERIPHERAL AND CENTRAL HYPEREXCITABILITY - DIFFERENTIAL SIGNS AND SYMPTOMS IN PERSISTENT PAIN", Behavioral and brain sciences, 20(3), 1997, pp. 404

Abstract

This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think of central sensitization as comprised of both an initial central sensitization and an ongoing central sensitization driven by inputs from peripheral sources. Each of these factors, initial sensitization, ongoing central sensitization, and inputs from peripheral sources, contributes to the net activity in dorsal horn neurons and thus influences the expression of persistent pain or hyperalgesia. Since each factor, peripheral inputs and central sensitization (initial or ongoing), can contribute to both the initiation and maintenance of persistent pain, therapies should target both peripheral and central sources of pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:28:28