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Titolo:
DUAL-COLOR FISH ANALYSIS OF BREAKPOINTS ON ROBERTSONIAN TRANSLOCATIONS
Autore:
TAKAHASHI Y; FUJITA H; NAKAMURA Y; KURAHASHI H;
Indirizzi:
OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT MED GENET,DIV CLIN GENET,2-2 YAMADAOKA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT MED GENET,DIV CLIN GENET OSAKA565 JAPAN MITSUBISHI KAGAKU BIOCLIN LABS INC OSAKA 565 JAPAN UNIV TOKYO,INST MED SCI,MOL MED LAB,MINATO KU TOKYO 108 JAPAN
Titolo Testata:
Japanese journal of human genetics
fascicolo: 4, volume: 42, anno: 1997,
pagine: 517 - 523
SICI:
0916-8478(1997)42:4<517:DFAOBO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUORESCENCE INSITU HYBRIDIZATION; HUMAN ACROCENTRIC CHROMOSOMES; COSMID MARKERS; SATELLITE DNA; ISOCHROMOSOMES; IDENTIFICATION; LOCALIZATION; REGIONS;
Keywords:
ROBERTSONIAN TRANSLOCATIONS; FISH; BREAKPOINTS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takahashi et al., "DUAL-COLOR FISH ANALYSIS OF BREAKPOINTS ON ROBERTSONIAN TRANSLOCATIONS", JPN J HUM G, 42(4), 1997, pp. 517-523

Abstract

We investigated six Robertsonian translocations, including two cases of rob(13q14q), one of rob(14q21q), one of rob(13q22q), and two of rob(21q21q), by means of fluorescence in situ hybridization (FISH) using five repetitive DNA probes: two alpha-satellite DNAs (D21Z1/D13Z1 and D14Z1/D22Z1), satellite III DNA, beta-satellite DNA, and ribosomal DNA. Single color FISH successfully defined the breakpoints in four casesof the six. Since the remaining two cases, rob(13q22q) and rob(21q21q), revealed to retain rDNA, we tried to define the breakpoints in detail by dual color FISH in these rare types. In the rob(13q22q) the chromosomal breakage on chromosome 22 was likely to have occurred within the rDNA region and that the chromosome 13 breakpoint was within the alpha-satellite region. In one rob(21q21q) case we defined the breakpoint on one chromosome distal to, or within, the beta-satellite region distal to the rDNA, and the other chromosome breakage had occurred within alpha-satellite DNA. Our results underscored the power of dual-colorFISH for defining the precise locations of breakpoints in Robertsonian translocations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:03:08