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Titolo:
[F-18] CFT ([F-18]WIN-35,428), A RADIOLIGAND TO STUDY THE DOPAMINE TRANSPORTER WITH PET - CHARACTERIZATION IN HUMAN-SUBJECTS
Autore:
LAAKSO A; BERGMAN J; HAAPARANTA M; VILKMAN H; SOLIN O; HIETALA J;
Indirizzi:
UNIV TURKU,DEPT PHARMACOL & CLIN PHARMACOL,KIINAMYLLYNKATU 10 FIN-20520 TURKU FINLAND TURKU PET CTR,ACCELERATOR LAB TURKU 20502 FINLAND RADIOPHARMACEUT CHEM LAB TURKU 20520 FINLAND TURKU PET CTR,MED PET TURKU 20520 FINLAND UNIV TURKU,CENT HOSP,DEPT PSYCHIAT FIN-20520 TURKU FINLAND
Titolo Testata:
Synapse
fascicolo: 3, volume: 28, anno: 1998,
pagine: 244 - 250
SICI:
0887-4476(1998)28:3<244:[C(ART>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; COCAINE RECOGNITION SITES; CFT )H-3>WIN 35,428; MONKEY BRAIN; H-3 CFT; BINDING-SITES; RECEPTOR-BINDING; REUPTAKE SITES; C-11 CFT; INVIVO;
Keywords:
F-18; DOPAMINE REUPTAKE SITES; POSITRON EMISSION TOMOGRAPHY; COCAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Laakso et al., "[F-18] CFT ([F-18]WIN-35,428), A RADIOLIGAND TO STUDY THE DOPAMINE TRANSPORTER WITH PET - CHARACTERIZATION IN HUMAN-SUBJECTS", Synapse, 28(3), 1998, pp. 244-250

Abstract

We have characterized the usage of [F-18]CFT (also known as [F-18]WIN35,428) as a radioligand for in vivo studies of human dopamine transporter by PET. CFT was labeled with F-18 to a high specific activity, and dynamic PET scans were conducted in healthy volunteers at various time points up to 5 h from [F-18]CFT injection. The regional distribution of [F-18]CFT uptake correlated well with the known distribution of dopaminergic nerve terminals in the human brain and also with that of other dopamine transporter radioligands. Striatal binding peaked at 225 min after injection and declined thereafter, demonstrating the reversible nature of the binding to the dopamine transporter. Therefore, due to the relatively long half-life of F-18 (109.8 min), PET scans with[F-18]CFT could easily be conducted during the binding equilibrium, allowing estimation of B-max/K-d values (i.e., binding potential). Binding potentials for putamen and caudate measured at equilibrium were 4.79 +/- 0.11 and 4.50 +/- 0.23, respectively. We were able to also visualize midbrain dopaminergic neurons (substantia nigra) with [F-18]CFT in some subjects. In conclusion, the labeling of CFT with F-18 allows PET scans to be conducted at binding equilibrium, and therefore a highsignal-to-noise ratio and reliable quantification of binding potential can be achieved. With a high resolution 3D PET scanner, the quantification of extrastriatal dopamine transporters should become possible. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:02:09