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Titolo:
CONTROLLED COMPARISON OF ELECTROPHYSIOLOGICAL SLEEP IN FAMILIES OF PROBANDS WITH UNIPOLAR DEPRESSION
Autore:
GILES DE; KUPFER DJ; RUSH AJ; ROFFWARG HP;
Indirizzi:
UNIV ROCHESTER,MED CTR,DEPT PSYCHIAT,300 CRITTENDEN BLVD ROCHESTER NY14642 UNIV ROCHESTER,MED CTR,DEPT NEUROL ROCHESTER NY 14642 UNIV PITTSBURGH,MED CTR,DEPT PSYCHIAT PITTSBURGH PA 00000 UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 00000
Titolo Testata:
The American journal of psychiatry
fascicolo: 2, volume: 155, anno: 1998,
pagine: 192 - 199
SICI:
0002-953X(1998)155:2<192:CCOESI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; PSYCHIATRIC-DISORDERS; EEG SLEEP; POLYSOMNOGRAPHIC FINDINGS; MAJOR DEPRESSION; REM LATENCY; HIGH-RISK; METAANALYSIS; RELIABILITY; RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Giles et al., "CONTROLLED COMPARISON OF ELECTROPHYSIOLOGICAL SLEEP IN FAMILIES OF PROBANDS WITH UNIPOLAR DEPRESSION", The American journal of psychiatry, 155(2), 1998, pp. 192-199

Abstract

Objective: This study presents polysomnographic data and psychiatric history for parents and siblings of probands with unipolar depression and short REM latency, probands with unipolar depression and normal REM latency, and normal comparison probands. Method: Parents and adult siblings (N = 252) of probands (N = 64) were evaluated for lifetime history of psychiatric disorders and were studied in the sleep laboratoryfor 3 nights. Results: REM latency predicted lifetime history of major depression. Short REM latency was also associated with slow wave sleep deficits. Rate of short REM latency in relatives of depressed probands with short REM latency quadrupled the rate in relatives of both depressed problems with normal REM latency and normal probands. Lifetimerisk of depression was almost twice as high in relatives of depressedprobands with short REM latency as in relatives of depressed probandswith normal REM latency. Conclusions: Short REM latency and slow wavesleep deficits are familial. Short REM latency is associated with increased risk of major depression beyond the familial risk associated with a depressed proband. Polysomnographic abnormalities also occurred in unaffected relatives. Although the data can be considered only suggestive, these findings indicate that polysomnographic abnormalities mayprecede the clinical expression of depression and may be useful in identifying those at highest risk for the illness.

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Documento generato il 31/03/20 alle ore 10:08:22