Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LACK OF SENSITIZATION TO THE EFFECTS OF D-AMPHETAMINE AND APOMORPHINEON SENSORIMOTOR GATING IN RATS
Autore:
DRUHAN JP; GEYER MA; VALENTINO RJ;
Indirizzi:
UNIV PENN,DEPT PSYCHIAT,MED RES SERV,PHILADELPHIA VET ADM MED CTR PHILADELPHIA PA 19104 ALLEGHENY UNIV HLTH SCI,DEPT PSYCHIAT PHILADELPHIA PA 19102 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT LA JOLLA CA 92093
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 135, anno: 1998,
pagine: 296 - 304
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR AGONISTS; ACOUSTIC STARTLE REFLEX; FREELY MOVING RATS; PREPULSE INHIBITION; BEHAVIORAL SENSITIZATION; SCHIZOPHRENIC-PATIENTS; PREFRONTAL CORTEX; ANIMAL-MODEL; OPEN-FIELD; LOCOMOTOR;
Keywords:
PREPULSE INHIBITION; SENSORIMOTOR GATING; SENSITIZATION; LOCOMOTOR ACTIVITY; AMPHETAMINE; APOMORPHINE; SCHIZOPHRENIA; STARTLE; DOPAMINE RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Druhan et al., "LACK OF SENSITIZATION TO THE EFFECTS OF D-AMPHETAMINE AND APOMORPHINEON SENSORIMOTOR GATING IN RATS", Psychopharmacology, 135(3), 1998, pp. 296-304

Abstract

This study assessed whether repeated injections of d-amphetamine or apomorphine could induce sensitization to the disruptive effects of these psychomotor stimulants on sensorimotor gating in rats, In the firstexperiment, rats were given six pre-exposures to either 2.0 mg/kg d-amphetamine or saline before being tested for the effects of d-amphetamine (0.0, 0.5, 1.0, 2.0 or 4.0 mg/kg, IF) on prepulse inhibition of acoustic startle (PPI) and locomotor activity. The tests for PPI confirmed that sensorimotor,eating could be disrupted by a high dose of il-amphetamine (4.0 mg/kg), However, comparison of the dose-response curvesfor the drug and saline pre-exposed groups did not reveal evidence for sensitization to this d-amphetamine effect in drug-pre-exposed rats,despite indications that sensitization had developed to the locomotorstimulant effects of LJ-amphetamine. A similar pattern of results wasobtained in a second experiment that examined the effects of apomorphine (0.0, 0.1, 0.2, 0.4 and 0.8 mg/kg, SC) on PPI and locomotion in rats pre-exposed to 2.0 mg/kg of this drug or its vehicle, These findings demonstrate that treatments which induce sensitization to the behavioral activating effects of psychomotor stimulants do not necessarily produce sensitization to the disruptive effects of stimulants on sensorimotor gating. The implications of these results for hypotheses linking sensitization-like processes to the etiology of schizophrenia are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:19:23