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Titolo:
P2X(2) RECEPTOR SUBUNIT EXPRESSION IN A SUBPOPULATION OF COCHLEAR TYPE-I SPIRAL GANGLION NEURONS
Autore:
SALIH SG; HOUSLEY GD; BURTON LD; GREENWOOD D;
Indirizzi:
UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHYSIOL,MOL PHYSIOL LAB,PRIVATEBAG 92019 AUCKLAND NEW ZEALAND UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHYSIOL,MOL PHYSIOL LAB AUCKLAND NEW ZEALAND
Titolo Testata:
NeuroReport
fascicolo: 2, volume: 9, anno: 1998,
pagine: 279 - 282
SICI:
0959-4965(1998)9:2<279:PRSEIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION CHANNELS; ADENOSINE 5'-TRIPHOSPHATE; MAMMALIAN COCHLEA; ATP;
Keywords:
ATP-GATED ION CHANNEL; AUDITORY; COCHLEA; DIRECT IN SITU RT-PCR; NEUROTRANSMISSION; RAT; SPIRAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Salih et al., "P2X(2) RECEPTOR SUBUNIT EXPRESSION IN A SUBPOPULATION OF COCHLEAR TYPE-I SPIRAL GANGLION NEURONS", NeuroReport, 9(2), 1998, pp. 279-282

Abstract

SPIRAL ganglion neurones in rat cochlea express three different isoforms of the P2X(2) receptor subunit which assemble into ATP-gated ion channels. Two of these P2X(2)R subunit isoforms have previously been detected in other auditory tissues. The third isoform (designated P2X(2-3)R) has not been described. This isoform lacks 39 bp immediately prior to the stop codon, corresponding to a 13 amino acid deletion of the extreme C-terminus domain. Using direct in situ RT-PCR, expression of P2X(2)R mRNA was confined to a subpopulation of type I spiral ganglionneurones. This study supports a role for extracellular ATP as a neurotransmitter for a discrete population of auditory neurones where variation in P2X(2)R isoform assembly may confer functional heterogeneity, including enhanced desensitization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:42:19