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Titolo:
ROLE OF THE ADRENAL MEDULLAE IN MALE AND FEMALE DOCA-SALT HYPERTENSIVE RATS
Autore:
LANGE DL; HAYWOOD JR; HINOJOSALABORDE C;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR PHYSIOL,7703 FLOYD CURL DR SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284
Titolo Testata:
Hypertension
fascicolo: 1, volume: 31, anno: 1998,
parte:, 2 supplemento:, S
pagine: 403 - 408
SICI:
0194-911X(1998)31:1<403:ROTAMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC RESPONSES; RECEPTOR ANTAGONIST; SEXUAL DIMORPHISM; VASOPRESSIN; MAINTENANCE; REACTIVITY; STRESS;
Keywords:
SEX DIFFERENCES; DOCA-SALT HYPERTENSION; RADIOTELEMETRY; BLOOD PRESSURE; HEART RATE; ADRENAL MEDULLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Lange et al., "ROLE OF THE ADRENAL MEDULLAE IN MALE AND FEMALE DOCA-SALT HYPERTENSIVE RATS", Hypertension, 31(1), 1998, pp. 403-408

Abstract

Female rats treated with deoxycorticosterone acetate (DOCA) and salt do not get as hypertensive as male DOCA-salt treated rats. The adrenalgland contributes to the development and maintenance of DOCA-salt hypertension in male rats. However, little is known about adrenal medullary function in DOCA-salt hypertensive female rats. This study tested the hypothesis that bilateral removal of the adrenal medullae would result in a greater fall in blood pressure in male DOCA-salt compared to female DOCA-salt rats. Five weeks after initiating DOCA-salt treatment, average 24 hour mean arterial pressure (MAP) in female rats was significantly attenuated compared to male rats (142+/-4 versus 168+/-6 mm Hg, respectively). Female DOCA-salt rats consumed significantly more saline per day than male DOCA-salt rats (22.3+/-1.8 versus 33.4+/-1.8 mL/100 prams body weight, respectively), Following adrenal medullectomy, DOCA-salt males experienced a significant decrease in MAP during thedark period after surgery (182+/-4 to 154+/-4 mm Hg) that was not observed in female DOCA-salt rats (150+/-6 to 135+/-3 mm Hg). In the following light period, MAP remained significantly decreased when comparedto the light period before surgery in DOCA-salt male (171+/-4 to 156+/-4 mm Hg), while no effect was observed in DOCA-salt female rats. Adrenal medullectomy significantly increased heart rate (HR) in all groups for 12 days. Male sham and DOCA-salt rats had significantly higher catecholamine content in the adrenal medulla than female sham and DOCA-salt rats, respectively. These data suggest that the adrenal medullae contribute more to the maintenance of blood pressure in DOCA-salt hypertension in male rats than female rats.

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Documento generato il 24/09/20 alle ore 10:48:36