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Titolo:
NEFAZODONE AND REM-SLEEP - HOW DO ANTIDEPRESSANT DRUGS DECREASE REM-SLEEP
Autore:
VOGEL G; COHEN J; MULLIS D; KENSLER T; KAPLITA S;
Indirizzi:
GMHI,SLEEP LAB,1256 BRIARCLIFF RD NE ATLANTA GA 30306 SLEEP RES LAB INC ATLANTA GA 00000
Titolo Testata:
Sleep
fascicolo: 1, volume: 21, anno: 1998,
pagine: 70 - 77
SICI:
0161-8105(1998)21:1<70:NAR-HD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; SPONTANEOUS FIRING RATE; ANTI-DEPRESSANT DRUGS; DORSAL RAPHE NEURONS; DOUBLE-BLIND; MAJOR DEPRESSION; HEALTHY-VOLUNTEERS; FLUOXETINE; WAKEFULNESS; IMIPRAMINE;
Keywords:
NEFAZODONE; REM SLEEP; SEROTONIN; ANTIDEPRESSANT DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
G. Vogel et al., "NEFAZODONE AND REM-SLEEP - HOW DO ANTIDEPRESSANT DRUGS DECREASE REM-SLEEP", Sleep, 21(1), 1998, pp. 70-77

Abstract

In previous uncontrolled studies, nefazodone, a new antidepressant drug, increased REM sleep or had no effect on REM sleep. We report a double-blind, placebo-controlled, parallel group study on effects of nefazodone (N) on polysomnographic sleep variables in healthy human volunteers. Nefazodone was administered for 16 consecutive days, and nocturnal sleep, as well as multiple sleep latency test (MSLT), was monitoredbefore, during, and after N administration. We found that N had no effect on any measured REM sleep variable including REM sleep duration, REM density, and nocturnal REM sleep distribution, Nefazodone also hadno significant effect on nocturnal total sleep time or NREM variables, but increased daytime alertness measured by the MSLT. Since N is a potent serotonin reuptake blocker, the present findings that N had no effect on REM sleep cast doubt on the hypothesis that antidepressant drugs decrease REM sleep by increasing serotonergic neurotransmission. Areview of other relevant work also casts doubt on this hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:56:42