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Titolo:
CALCULATION OF THE FDG LUMPED CONSTANT BY SIMULTANEOUS MEASUREMENTS OF GLOBAL GLUCOSE AND FDG METABOLISM IN HUMANS
Autore:
HASSELBALCH SG; MADSEN PL; KNUDSEN GM; HOLM S; PAULSON OB;
Indirizzi:
NATL UNIV HOSP,RIGSHOSP,NEUROBIOL RES UNIT N9201,9 BLEGDAMSVEJ DK-2100 COPENHAGEN DENMARK NATL UNIV HOSP,RIGSHOSP,DEPT NEUROL DK-2100 COPENHAGEN DENMARK NATL UNIV HOSP,RIGSHOSP,DEPT NUCL MED DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 2, volume: 18, anno: 1998,
pagine: 154 - 160
SICI:
0271-678X(1998)18:2<154:COTFLC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
KETY-SCHMIDT TECHNIQUE; RAT-BRAIN; PHOSPHORYLATION; DEOXYGLUCOSE; TOMOGRAPHY; TRANSPORT;
Keywords:
POSITRON EMISSION TOMOGRAPHY; F-18 FLURO-DEOXY-D-GLUCOSE; LUMPED CONSTANT; BRAIN GLUCOSE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Hasselbalch et al., "CALCULATION OF THE FDG LUMPED CONSTANT BY SIMULTANEOUS MEASUREMENTS OF GLOBAL GLUCOSE AND FDG METABOLISM IN HUMANS", Journal of cerebral blood flow and metabolism, 18(2), 1998, pp. 154-160

Abstract

The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDGas tracer (CMRFDG), Fifteen healthy, normal volunteers (mean age 24 +/- 4 years) were studied. Global CBF and CMRglc were measured with theKety-Schmidt technique using Xe-133 as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynamic and single-scan methods and the K-1-k(3) model. Measurements with the Kety-Schmidt technique and PET-FDG were performed simultaneously. Global CBF was 47.1 +/- 8.0 mL.100 g(-1).min(-1), and CMRglc was 22.8 +/- 4.1 mu mol.100 g(-1).min(-1). No difference in CMRFDG was found with the two methods (17.8 +/-1.6 and 18.2 +/- 1.3 mu mol.100 g(-1).min(-1), dynamic and single scan methods, respectively). Accordingly, the lumped constant ranged from0.80 +/- 0.16 to 0.82 +/- 0.15, with a mean value of 0.81 +/- 0.15. The mean ratio between phosphorylation of FDG and glucose (k(3)/k(3)) was 0.39 +/- 0.15. The discrepancy between the lumped constant determined in this study and previously obtained values can be explained partly by methodologic problems, and we conclude that most of the discrepancy results from previous overestimation of global CBF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:51:37