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Titolo:
INCREASED FUNCTIONAL VASCULAR-RESPONSE IN THE REGION OF A GLIOMA
Autore:
OJEMANN JG; NEIL JM; MACLEOD AM; SILBERGELD DL; DACEY RG; PETERSEN SE; RAICHLE ME;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG,BOX 8057,660 S EUCLID AVE STLOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT RADIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL,NEUROIMAGING LAB ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MCDONNELL CTR HIGHER BRAIN FUNCT ST LOUIS MO 63110
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 2, volume: 18, anno: 1998,
pagine: 148 - 153
SICI:
0271-678X(1998)18:2<148:IFVITR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; HUMAN-BRAIN; INTRAVENOUS (H2O)-O-15; PET IMAGES; ANATOMY; LOCALIZATION; GENERATION; TUMOR; MRI;
Keywords:
ACTIVATION; LANGUAGE; TUMOR; ASTROCYTOMA; SUPPLEMENTARY MOTOR AREA; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Ojemann et al., "INCREASED FUNCTIONAL VASCULAR-RESPONSE IN THE REGION OF A GLIOMA", Journal of cerebral blood flow and metabolism, 18(2), 1998, pp. 148-153

Abstract

Functional imaging of a language task using positron emission tomography was performed as parr of the preoperative assessment of a patient with a left supplementary motor area (SMA) tumor. Positron emission tomography scans were obtained during language tasks (verb generation and word reading of visually presented nouns) that normally lead to increased brood flow in the SMA relative to a control condition (visual fixation). In the patient, the normal SMA response was an order of magnitude larger in the region of the tumor. Other regions: such as left inferior frontal cortex and right cerebellum, showed equivalent activation in the patient and normal subjects, Histopathologic study revealed an anaplastic astrocytoma. Thus, this exaggerated vascular response tolocal neuronal activation occurred in the setting of a proliferation of glial cells. This is consistent with models of coupling of regionalCBF and neuronal activity that implicate glia as the mediator betweenneurons and vasculature. The concept that tumoral disruption of normal vascular responses could, in some cases, potentially enhance rather than dampen the response is proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:08:46