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Titolo:
EVALUATION OF HEMORHEOLOGICAL AND MICROCIRCULATORY DISTURBANCES IN CHRONIC VENOUS INSUFFICIENCY - ACTIVITY OF DAFLON 500 MG
Autore:
LEDEVEHAT C; KHODABANDEHLOU T; VIMEUX M; KEMPF C;
Indirizzi:
CTR HOSP,UNITE RECH HEMORHEOL CLIN F-58000 NEVERS FRANCE CTR HOSP,SERV DIABETOL ENDOCRINOL NUTR F-58000 NEVERS FRANCE ICD OTTROT FRANCE
Titolo Testata:
International journal of microcirculation, clinical and experimental
, volume: 17, anno: 1997, supplemento:, 1
pagine: 27 - 33
SICI:
0167-6865(1997)17:<27:EOHAMD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER; TRANSCUTANEOUS OXYMETRY; SKIN; ACCUMULATION; AGGREGATION; CELLS;
Keywords:
RED BLOOD CELL AGGREGATION/DISAGGREGATION; LASER DOPPLER FLUXMETRY; TRANSCUTANEOUS OXYGEN PRESSURE; WHITE CELL COUNTS; NEUTROPHIL ACTIVITY; DAFLON 500 MG;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C. Ledevehat et al., "EVALUATION OF HEMORHEOLOGICAL AND MICROCIRCULATORY DISTURBANCES IN CHRONIC VENOUS INSUFFICIENCY - ACTIVITY OF DAFLON 500 MG", International journal of microcirculation, clinical and experimental, 17, 1997, pp. 27-33

Abstract

The use of Daflon 500 mg has been shown to improve venous tone, microvascular permeability, lymphatic activity, and microcirculatory nutritive flow. This study aimed to assess the effects of Daflon 500 mg at adaily dose of 2 tab/day on microcirculatory, haemorheologic parameters, white blood cell counts and neutrophil activation in patients suffering from chronic venous insufficiency (CVI). This was a single-centredouble-blind placebo-controlled study comparing two parallel groups of CVI patients who were treated for 2 months with Daflon 500 mg (n = 39) or placebo (n = 38). Evaluations were performed before treatment (D-0) and at the end of treatment (D-60) Blood samples were drawn from afoot vein before and at the end of a 15-min period of venous hypertension provoked by a cuff inflated to 100 mm Hg. Red blood cell (RBC) deformability was determined by the initial flow rate filtration technique using a Hanss haemorheometer. RBC aggregation was evaluated by a Myrenne aggregometer based on analysis of transmitted light through a blood sample during flow. RBC disaggregation was evaluated by Sefam erythro-aggregometer based on analysis of the backscattered light through a blood sample in a Couette flow. Microcirculatory parameters were assessed by means of laser Doppler fluxmetry and transcutaneous oxymetry measurements and consisted of continuous records of blood flux (BF) and TcPO2 before and during 15 min of venous hypertension. Results are expressed as absolute values at baseline (before stasis) and at the endof stasis, before and after 2 months of treatment. Univariate analysis showed a significant reduction of the stasis-induced RBC aggregationindex (Daflon 500 mg: -0.07 +/- 0.20; placebo: 0.04 +/- 0.18; mean +/- SD; p = 0.03). Multivariate analysis identified a subset of 5 variables (RBC aggregation, RBC count, microcirculatory BF, amplitude and frequency of vasomotion) that produced a good discrimination model between the two treatments. Linear combination of these 5 variables in 48 patients with complete data showed a significant difference (p < 0.001)between the groups. These changes suggest a protective effect of Daflon 500 mg on the deleterious influence of stasis on microcirculatory (BF) and hemorheologic (RBC aggregation) parameters in CVI patients in comparison to patients receiving placebo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:38:53